EFFECT OF GABAB AGONIST AND ANTAGONIST MICROINJECTION INTO CUNEIFORMIS NUCLEUS (CNF) ON MORPHINE INDUCED ANTINOCICEPTION BY FORMALIN TEST IN RAT

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REZVANIPOUR M.; SHEYBANI VAHID; BAKHSHESH M.

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Journal: Journal of Rafsanjan University of Medical Sciences Year:2007 | Volume:6 | Issue:2 (23) Page(s): 101-108

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Title

EFFECT OF GABAB AGONIST AND ANTAGONIST MICROINJECTION INTO CUNEIFORMIS NUCLEUS (CNF) ON MORPHINE INDUCED ANTINOCICEPTION BY FORMALIN TEST IN RAT

Author(s)

REZVANIPOUR M. | SHEYBANI VAHID | BAKHSHESH M. | Issue Writer Certificate

Keywords

CUNEIFORMISQ3

CGP35348Q3

BACLOFENQ2

GABABQ3

MORPHINEQ3

Abstract

Background and Objective: There are several evidences that show CUNEIFORMIS nucleus is involved in nociception. In the present study the effect of intra CUNEIFORMIS microinjection of GABAB agonist (baclofen) and antagonist (CGP35348) on MORPHINE induced antinociception in rat were investigated.Materials and Methods: In this expremental study, through canulation of cuneifoprmis nucleus in rat the effect of intra CUNEIFORMIS (CNF) microinjection of GABAB receptor agonist (baclofen) and antagonist (CGP35348) on MORPHINE iduced antinociception were investigated by formalin test.Results: Microinjection of MORPHINE (10 mg /0.5 ml/saline) or different doses of BACLOFEN (0.25, 0.5, 1 m/gper rat) had antinociception in the both first and second phases of formalin test. The response induced by MORPHINE or BACLOFEN in both phases were reduced by CGP35348. The responses induced by combination of BACLOFEN (1mg per rat) and intraperitoneal (ip) injection of naloxan were reduced in both phases of formalin test. Microinjection of CGP35348 alone has produced antinociception in first phase of the formalin test. MORPHINE with different doses of BACLOFEN did not increase the antinociception effect whereas microinjection of CGP35348 administration significantly increased the antinociception in acute phase.Conclusion: It may be concluded that CNF GABAs receptor induced antinociception via opioid receptor in the formalin test.

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References

A STUDY ON THE EFFECT OF INTRACUNEIFORMIS NUCLEUS MICROINJECTION OF GABAA RECEPTOR AGONIST AND ANTAGONIST ON ANTINOCICEPTIVE EFFECTS OF MORPHINE BY FORMALIN TEST IN RAT

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APA: Copy

REZVANIPOUR, M., SHEYBANI, VAHID, & BAKHSHESH, M.. (2007). EFFECT OF GABA_B AGONIST AND ANTAGONIST MICROINJECTION INTO CUNEIFORMIS NUCLEUS (CNF) ON MORPHINE INDUCED ANTINOCICEPTION BY FORMALIN TEST IN RAT. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, 6(2 (23)), 101-108. SID. https://sid.ir/paper/70938/en

Vancouver: Copy

REZVANIPOUR M., SHEYBANI VAHID, BAKHSHESH M.. EFFECT OF GABA_B AGONIST AND ANTAGONIST MICROINJECTION INTO CUNEIFORMIS NUCLEUS (CNF) ON MORPHINE INDUCED ANTINOCICEPTION BY FORMALIN TEST IN RAT. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES[Internet]. 2007;6(2 (23)):101-108. Available from: https://sid.ir/paper/70938/en

IEEE: Copy

M. REZVANIPOUR, VAHID SHEYBANI, and M. BAKHSHESH, “EFFECT OF GABA_B AGONIST AND ANTAGONIST MICROINJECTION INTO CUNEIFORMIS NUCLEUS (CNF) ON MORPHINE INDUCED ANTINOCICEPTION BY FORMALIN TEST IN RAT,” JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, vol. 6, no. 2 (23), pp. 101–108, 2007, [Online]. Available: https://sid.ir/paper/70938/en

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