THE SURVEY OF ALOE VERA AQUEOUS EXTRACT AND GLIBENCLAMID INTERACTION ON BLOOD GLUCOSE, LFT AND LIPIDS DIABETIC INDUCED MALE RATS BY STREPTOZOTOCIN

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JADID ALESLAMI M.; ABBASNEZHAD MAHDI; SHAHRAKI M.R.

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Journal: JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES Year:2010 | Volume:9 | Issue:3 (36) Page(s): 185-194

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Title

THE SURVEY OF ALOE VERA AQUEOUS EXTRACT AND GLIBENCLAMID INTERACTION ON BLOOD GLUCOSE, LFT AND LIPIDS DIABETIC INDUCED MALE RATS BY STREPTOZOTOCIN

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JADID ALESLAMI M. | ABBASNEZHAD MAHDI | SHAHRAKI M.R. | Issue Writer Certificate

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Abstract

Background and Objectives: Aloe vera is native to North Africa, and is also cultivated in Turkey. Aloe has long been used all over the world for its various medicinal properties. The aim of this study was to measure the interaction effect of Aloe vera and glibenclamid on blood glucose, LFT and lipid metabolism in streptozotocine-induced diabetic male rats.Materials and Methods: This experimental study was carried out on 40 wistar Albino male rats in Zahedan University of Medical Sciences. Animals were divided into five groups, one as control (intact) , and the others as experimental groups. Rats in the experimental groups were made diabetic by streptozotocin injection (65mg/kg-IP). The diabetic groups, except one (diabetic control), received 400 mg/kg aloe vera extract, 5mg/kg glibenclamid and 400 mg/kg Aloe vera extract with 5 mg/kg glibenclamid daily for 4 weeks by gavages respectively. At the end of experiement fasting blood samples were collected from all groups.Results: The results showed that FBS, TG, Ch, AST, ALT levels in the experimental groups were significantly decreased in comparison with those in the control group (p<0.05) . There was no significant difference on HDL level. In addition, Alk.P level in glibenclamid alone and glibenclamid + Aloe vera groups were significantly increased in comparison with the control group (p<0.05). Conclusion: The results of this research indicate that interaction of Aloe vera aqueous extract and glibenclamid decrease blood glucose, TG, Ch, LDL, AST and ALT levels. However, the effect of Aloe vera extract in combination was not greater than the effect of Aloe vera extract alone. These findings may be due to the effects of Aloe vera and glibenclamid on glucose metabolism. Further research is suggested to study the exact mechanism of them in diabetic rat.

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APA: Copy

JADID ALESLAMI, M., ABBASNEZHAD, MAHDI, & SHAHRAKI, M.R.. (2010). THE SURVEY OF ALOE VERA AQUEOUS EXTRACT AND GLIBENCLAMID INTERACTION ON BLOOD GLUCOSE, LFT AND LIPIDS DIABETIC INDUCED MALE RATS BY STREPTOZOTOCIN. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, 9(3 (36)), 185-194. SID. https://sid.ir/paper/70970/en

Vancouver: Copy

JADID ALESLAMI M., ABBASNEZHAD MAHDI, SHAHRAKI M.R.. THE SURVEY OF ALOE VERA AQUEOUS EXTRACT AND GLIBENCLAMID INTERACTION ON BLOOD GLUCOSE, LFT AND LIPIDS DIABETIC INDUCED MALE RATS BY STREPTOZOTOCIN. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES[Internet]. 2010;9(3 (36)):185-194. Available from: https://sid.ir/paper/70970/en

IEEE: Copy

M. JADID ALESLAMI, MAHDI ABBASNEZHAD, and M.R. SHAHRAKI, “THE SURVEY OF ALOE VERA AQUEOUS EXTRACT AND GLIBENCLAMID INTERACTION ON BLOOD GLUCOSE, LFT AND LIPIDS DIABETIC INDUCED MALE RATS BY STREPTOZOTOCIN,” JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, vol. 9, no. 3 (36), pp. 185–194, 2010, [Online]. Available: https://sid.ir/paper/70970/en

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