The Antibacterial Activity and Phytochemical Compounds of Citrus grandis Extract Against Human Infective Bacteria

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Alamholo Mostafa; Shojaemehr Mohaddeseh

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Journal Paper

Paper Information

Journal: Journal of Kermanshah University of Medical Sciences Year:2020 | Volume:24 | Issue:3 Page(s): 0-0

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Information Journal Paper

Title

The Antibacterial Activity and Phytochemical Compounds of Citrus grandis Extract Against Human Infective Bacteria

Author(s)

Alamholo Mostafa | Shojaemehr Mohaddeseh | Issue Writer Certificate

Keywords

Antibacterial

Antioxidant

Citrus grandis

Secondary Metabolites

Abstract

Background: With the presence of Secondary Metabolites that have antimicrobial properties and bacterial resistance against antibiotics, medicinal plants have attracted the attention of researchers in the pharmaceutical industry. Objectives: The present study aimed to investigate the Antibacterial and Antioxidant activity and phytochemical compounds of Citrus grandis extract against human infection bacteria in-vitro. Methods: Samples of Citrus grandis were collected from the north of Iran and assessed in terms of the Antibacterial activity, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC) using the agar well diffusion method. In addition, the anti-radical activity was determined by DPPH, total phenols were measured using the Folin-Ciocalteu method, and flavonoids were determined using aluminum chloride. The presence of alkaloid, saponin, and tannin was also investigated. Data analysis was performed in SPSS. Results: The colored and white skin methanol extract of C. grandis indicated more significant inhibitory effects on Bacillus cereus, Staphylococcus aureus, and Micrococcus luteus. The total phenol content of the colored and white skin was estimated at 79. 71 and 71. 63 mgGA/g, and the flavonoid level was determined to be 3. 63 and 4. 06 mgQ/g, respectively. The IC50 of the colored and white skin methanol extract and ascorbic acid were estimated at 0. 1251, 0. 1376, and 0. 1095 mg. mL-1, respectively. The methanol extract of the colored skin showed the presence of alkaloid, while the white skin showed the presence of alkaloid and saponin. Conclusions: According to the results, the C. grandis extract had Antioxidant and Antibacterial properties due to the presence of Secondary Metabolites. Therefore, it is recommended that natural and rare drugs be produced to control pathogenic bacteria in the pharmaceutical industry.

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References

Antibacterial Activity of Alcoholic and Aqueous Extracts of Various Organs of Citrus medica on 10 Human Pathogenic in Vitro

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APA: Copy

Alamholo, Mostafa, & Shojaemehr, Mohaddeseh. (2020). The Antibacterial Activity and Phytochemical Compounds of Citrus grandis Extract Against Human Infective Bacteria. JOURNAL OF KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES (BEHBOOD), 24(3), 0-0. SID. https://sid.ir/paper/709709/en

Vancouver: Copy

Alamholo Mostafa, Shojaemehr Mohaddeseh. The Antibacterial Activity and Phytochemical Compounds of Citrus grandis Extract Against Human Infective Bacteria. JOURNAL OF KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES (BEHBOOD)[Internet]. 2020;24(3):0-0. Available from: https://sid.ir/paper/709709/en

IEEE: Copy

Mostafa Alamholo, and Mohaddeseh Shojaemehr, “The Antibacterial Activity and Phytochemical Compounds of Citrus grandis Extract Against Human Infective Bacteria,” JOURNAL OF KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES (BEHBOOD), vol. 24, no. 3, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/709709/en

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