EVALUATION OF THE EFFECT OF PERIPHERAL INJECTION OF CORTICOSTERONE ON ACUTE PAIN IN MICE: THE LIKELY INTERACTION WITH NITRIC OXIDE SYSTEM

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TAHERIAN ABAS ALI; VAFAEI A.A.; NESAEI ZEYNABAD M.N.

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Journal: JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES Year:2010 | Volume:9 | Issue:2 (35) Page(s): 79-88

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Title

EVALUATION OF THE EFFECT OF PERIPHERAL INJECTION OF CORTICOSTERONE ON ACUTE PAIN IN MICE: THE LIKELY INTERACTION WITH NITRIC OXIDE SYSTEM

Author(s)

TAHERIAN ABAS ALI | VAFAEI A.A. | NESAEI ZEYNABAD M.N. | Issue Writer Certificate

Keywords

PAINQ2

CORTICOSTERONEQ2

HOT PLATEQ3

TAIL FLICKQ3

L-ARGININEQ2

L-NITROARGININE METHYL ESTERQ3

Abstract

Background and Objectives: Previous studies have suggested that glucocorticoids have modulatory effects on acute PAIN, and possibly one of the mechanisms that mediate these effects is nitric oxide. The aim of this study was to determine the interaction between CORTICOSTERONE and Nitric Oxide (NO) system on acute PAIN in HOT PLATE (HP) and TAIL FLICK (TF) models in mice. Materials and Methods: This experimental study was done in Semnan physiology research center in 2008. One handered forty male albino mice (25-30 g) were used. For evaluation of acute PAIN, HP and TF tests were used. All animals received two IP injections, L-NAME (10 mg/kg) as a NO synthesis inhibitor or L-ARGININE (20 mg/kg), as a NO precursor or saline (6 ml/kg) for 60 min. Different doses of CORTICOSTERONE (I and 3 mg/kg) or Vehicle (Propylene glycol + Saline in 6 ml) were injected for 30 min before the evaluation tests. One way and two way ANOVA and Tukey test were used for data analysis. Results: Findings indicated that CORTICOSTERONE at doses of 1 and 3 mg significantly reduced acute PAIN reaction in mice (p<0.001). Also pretreatment of LA inhibited the analgesic effects of CORTICOSTERONE in both tests (p<0.05), while injection of LN did not have any significant effects. Conclusion: It is concluded that CORTICOSTERONE induced analgesic effects possibly through modulation of NO system. The increase of NO production inhibits this effect.

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APA: Copy

TAHERIAN, ABAS ALI, VAFAEI, A.A., & NESAEI ZEYNABAD, M.N.. (2010). EVALUATION OF THE EFFECT OF PERIPHERAL INJECTION OF CORTICOSTERONE ON ACUTE PAIN IN MICE: THE LIKELY INTERACTION WITH NITRIC OXIDE SYSTEM. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, 9(2 (35)), 79-88. SID. https://sid.ir/paper/71013/en

Vancouver: Copy

TAHERIAN ABAS ALI, VAFAEI A.A., NESAEI ZEYNABAD M.N.. EVALUATION OF THE EFFECT OF PERIPHERAL INJECTION OF CORTICOSTERONE ON ACUTE PAIN IN MICE: THE LIKELY INTERACTION WITH NITRIC OXIDE SYSTEM. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES[Internet]. 2010;9(2 (35)):79-88. Available from: https://sid.ir/paper/71013/en

IEEE: Copy

ABAS ALI TAHERIAN, A.A. VAFAEI, and M.N. NESAEI ZEYNABAD, “EVALUATION OF THE EFFECT OF PERIPHERAL INJECTION OF CORTICOSTERONE ON ACUTE PAIN IN MICE: THE LIKELY INTERACTION WITH NITRIC OXIDE SYSTEM,” JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, vol. 9, no. 2 (35), pp. 79–88, 2010, [Online]. Available: https://sid.ir/paper/71013/en

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