APOPTOSIS EFFECTS OF ALOE-EMODIN AGAINST MCF-7 CELL LINE

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HOSSEINI J.; MAHMOUDI M.; HAKHAMANESHI M.S.; JALILI A.; KHOSHDEL A.; SHEIKHFATHOLLAHI M.; FAKHARI SH.; HOSSEINI ZIJOUD S.M.

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Journal: JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES Year:2014 | Volume:13 | Issue:1 Page(s): 41-52

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Title

APOPTOSIS EFFECTS OF ALOE-EMODIN AGAINST MCF-7 CELL LINE

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Keywords

BREAST CANCERQ2

ALOE-EMODINQ2

APOPTOSISQ2

MCF-7Q2

Abstract

Background and Objective: ALOE-EMODIN is a Hydroxyanthraquinone that exists in Aloe Vera leaves and has been known to have anti-tumor effects. Various studies have mentioned the biological effects of Aloe Vera such as antiviral, antimicrobial and some hepato-protective effects. Recently its antitumor effects have attracted the attention of many researchers.BREAST CANCER is the most common malignancy in women, accounting for 30% of all female cancers and< 1%of all cancer cases in men. BREAST CANCER is also responsible for 15% of cancer deaths in women. The aim of the present study was to investigate the anti-cancer effects of ALOE-EMODIN on human BREAST CANCER MCF-7cell line.Materials and Methods: In this laboratory study MCF-7 cells were cultured in RPMI medium with 10% fetal bovine serum (FBS). The cytotoxic effect of different concentrations (5, 10, 25, 50, and 100 μM) of ALOE-EMODINon cultured cells were evaluated by MTT assayat different times (24, 48, 72 h). APOPTOSIS and CD95 (Fas) expression were analyzed by flow-cytometry using an Annexin V-FITC/PI kit and Fas (CD95) kit according to the manufacturer’s protocol.Results: ALOE-EMODIN decreases the viability of MCF-7 cell line in a time and dose dependent manner, so that the most effective concentration of this substance was100mM and 72 h after treatment. According to the data of Fas (CD95) expression and Annexin-PI, the highest APOPTOSIS induction rate was seen in 100μM and 72 h.Conclusion: The findings of the present study indicated that ALOE-EMODINhas has some antitumor effects and can be used in the treatment of BREAST CANCER. However, further investigation of its cytotoxic effects against tumor cells, both in vitro and in vivo, is recommended.

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APA: Copy

HOSSEINI, J., MAHMOUDI, M., HAKHAMANESHI, M.S., JALILI, A., KHOSHDEL, A., SHEIKHFATHOLLAHI, M., FAKHARI, SH., & HOSSEINI ZIJOUD, S.M.. (2014). APOPTOSIS EFFECTS OF ALOE-EMODIN AGAINST MCF-7 CELL LINE. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, 13(1), 41-52. SID. https://sid.ir/paper/71042/en

Vancouver: Copy

HOSSEINI J., MAHMOUDI M., HAKHAMANESHI M.S., JALILI A., KHOSHDEL A., SHEIKHFATHOLLAHI M., FAKHARI SH., HOSSEINI ZIJOUD S.M.. APOPTOSIS EFFECTS OF ALOE-EMODIN AGAINST MCF-7 CELL LINE. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES[Internet]. 2014;13(1):41-52. Available from: https://sid.ir/paper/71042/en

IEEE: Copy

J. HOSSEINI, M. MAHMOUDI, M.S. HAKHAMANESHI, A. JALILI, A. KHOSHDEL, M. SHEIKHFATHOLLAHI, SH. FAKHARI, and S.M. HOSSEINI ZIJOUD, “APOPTOSIS EFFECTS OF ALOE-EMODIN AGAINST MCF-7 CELL LINE,” JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, vol. 13, no. 1, pp. 41–52, 2014, [Online]. Available: https://sid.ir/paper/71042/en

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