The Role of Estrogen Receptors of Paragigantocellularis Lateralis Nucleus in the Formalin-Induced Pain Modulation in Female Rats

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KHAKPAY R.; HEIDARZADEH Z.; Khakpai F.

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Journal: JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES Year:2018 | Volume:17 | Issue:7 Page(s): 597-610

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Title

The Role of Estrogen Receptors of Paragigantocellularis Lateralis Nucleus in the Formalin-Induced Pain Modulation in Female Rats

Author(s)

KHAKPAY R. | HEIDARZADEH Z. | Khakpai F. | Issue Writer Certificate

Keywords

17β-EstradiolQ1

Estrus phaseQ1

ICI182Q1

780Q1

Pain modulationQ3

Paragigantocellularis lateralis nucleusQ2

Female ratQ2

Abstract

Background and Objectives: Since intra-paragigantocellularis lateralis (LPGi) injection of 17β-Estradiol induces strong analgesia in male rats which might be mediated via estrogen receptors, this study investigated the role of estrogen receptors of LPGi nucleus in the modulation of formalin-induced pain (while being stimulated by 17β-Estradiol) during Estrus phase in Female rats. Materials and Methods: In this experimental study, 48 female Wistar rats (200-270 gr) were randomly divided into 8 groups including control, sham, normal saline (17β-Estradiol solvent), DMSO (ICI182, 780 solvent), 17β-Estradiol, estrogen receptor antagonist (ICI182, 780; 15&50 nmol) and ICI182, 780/17β-Estradiol. After entrance into the Estrus phase, drugs were injected into the LPGi nucleus; 15 minutes later, formalin injection (5%, 50 μ l) was done into the left rat's hind paw and formalin-induced paw jerking behavior was recorded for 1 hr. Data were analyzed using one-way ANOVA analysis followed by Tukey multiple comparison test. Results: The results of this research showed that during Estrus phase, the treatment of LPGi nucleus with 17β-Estradiol significantly attenuated paw jerking behavior in the both phases of formalin test (p<0. 001). Pretreatment of the LPGi nucleus with ICI182, 780 prevented the 17β-Estradiol-induced antinociception (p<0. 001). Conclusion: Based on these results, it can be suggested that intra-LPGi injection of 17β-Estradiol induces robust analgesia during the Estrus phase in Female rats; and this effect may be mediated via estrogen receptors.

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APA: Copy

KHAKPAY, R., HEIDARZADEH, Z., & Khakpai, F.. (2018). The Role of Estrogen Receptors of Paragigantocellularis Lateralis Nucleus in the Formalin-Induced Pain Modulation in Female Rats. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, 17(7 ), 597-610. SID. https://sid.ir/paper/71055/en

Vancouver: Copy

KHAKPAY R., HEIDARZADEH Z., Khakpai F.. The Role of Estrogen Receptors of Paragigantocellularis Lateralis Nucleus in the Formalin-Induced Pain Modulation in Female Rats. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES[Internet]. 2018;17(7 ):597-610. Available from: https://sid.ir/paper/71055/en

IEEE: Copy

R. KHAKPAY, Z. HEIDARZADEH, and F. Khakpai, “The Role of Estrogen Receptors of Paragigantocellularis Lateralis Nucleus in the Formalin-Induced Pain Modulation in Female Rats,” JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, vol. 17, no. 7 , pp. 597–610, 2018, [Online]. Available: https://sid.ir/paper/71055/en

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