INTERACTION BETWEEN NITRIC OXIDE AND HISTAMINERGIC H1 RECEPTOR OF DORSAL HIPPOCAMPUS IN THE ELEVATED PLUS-MAZE OF ANXIETY

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PIRI M.; ASGARIYAN M.; BANANEJ M.; SHAHIN M.S.; ZARRINDAST M.R.

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Journal: JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES Year:2013 | Volume:11 | Issue:6 (47) Page(s): 545-556

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Title

INTERACTION BETWEEN NITRIC OXIDE AND HISTAMINERGIC H1 RECEPTOR OF DORSAL HIPPOCAMPUS IN THE ELEVATED PLUS-MAZE OF ANXIETY

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Keywords

NITRIC OXIDEQ2

PYRILAMINEQ2

HISTAMINE H1 RECEPTORSQ2

ELEVATED PLUS MAZEQ2

MOUSEQ2

Abstract

Background and Objectives: NITRIC OXIDE and HISTAMINE H1 RECEPTORS influence anxiety-like behaviors.Furthermore, interaction between NITRIC OXIDE and HISTAMINE H1 RECEPTORS has been demonstrated in the modulation of some behavior. The present study was designed to evaluate the interactions between PYRILAMINE, aH1 receptor antagonist and NITRIC OXIDE systems in the CA1 brain region of the mice using the plus-maze test.Materials and Methods: In this experimental study, 136 adult male NMRI mice were anesthetized with ketamine and xylazine and two cannuale were inserted stereotaxically into the CA1 region of the dorsal hippocampus. After 1 week recovery, the ELEVATED PLUS MAZE test was used to test the anxiety-like behaviors.Results: Intra-CA1 injection of PYRILAMINE induced anxiety. Intra-CA1 injection L-arginine (0.1 and 0.5mg/mouse) or L-NAME (5, 10 ng/mouse) 2 min after befor effective dose of PYRILAMINE (9 mg/mouse) inhibited anxiogenic effects of PYRILAMINE.Conclusion: These results show that there are complex interactions between HISTAMINE H1 RECEPTORS and NITRIC OXIDE system that affect anxiety behaviors in the CA1 region of dorsal hippocampus. Activation or inhibition of NITRIC OXIDE system inhibits anxiogenic response of PYRILAMINE in the dorsal hippocampus.

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APA: Copy

PIRI, M., ASGARIYAN, M., BANANEJ, M., SHAHIN, M.S., & ZARRINDAST, M.R.. (2013). INTERACTION BETWEEN NITRIC OXIDE AND HISTAMINERGIC H1 RECEPTOR OF DORSAL HIPPOCAMPUS IN THE ELEVATED PLUS-MAZE OF ANXIETY. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, 11(6 (47)), 545-556. SID. https://sid.ir/paper/71148/en

Vancouver: Copy

PIRI M., ASGARIYAN M., BANANEJ M., SHAHIN M.S., ZARRINDAST M.R.. INTERACTION BETWEEN NITRIC OXIDE AND HISTAMINERGIC H1 RECEPTOR OF DORSAL HIPPOCAMPUS IN THE ELEVATED PLUS-MAZE OF ANXIETY. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES[Internet]. 2013;11(6 (47)):545-556. Available from: https://sid.ir/paper/71148/en

IEEE: Copy

M. PIRI, M. ASGARIYAN, M. BANANEJ, M.S. SHAHIN, and M.R. ZARRINDAST, “INTERACTION BETWEEN NITRIC OXIDE AND HISTAMINERGIC H1 RECEPTOR OF DORSAL HIPPOCAMPUS IN THE ELEVATED PLUS-MAZE OF ANXIETY,” JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, vol. 11, no. 6 (47), pp. 545–556, 2013, [Online]. Available: https://sid.ir/paper/71148/en

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