ALTERATION IN Α AND Β ADRENOCEPTOR PROFILE OF RABBIT KNEE JOINT BLOOD VESSELS DUE TO ACUTE INFLAMMATION

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NAJAFIPOUR H.; SHEYBANI VAHID

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Journal: JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES Year:2002 | Volume:1 | Issue:3 Page(s): 146-156

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Title

ALTERATION IN Α AND Β ADRENOCEPTOR PROFILE OF RABBIT KNEE JOINT BLOOD VESSELS DUE TO ACUTE INFLAMMATION

Author(s)

NAJAFIPOUR H. | SHEYBANI VAHID | Issue Writer Certificate

Keywords

ACUTE INFLAMMATIONQ4

Α AND Β ADRENOCEPTORQ4

KNEE JOINTQ3

VESSELS RABBITQ4

Abstract

Background: This experiment was planned to investigate the nature of α- and β- adrenoceptor in blood vessels supplying the posterior capsule of the acutely inflamed rabbit KNEE JOINT, and results were compared to findings from previous experiments on the normal joint, to assess any alteration which may occur in the adrenoceptor profile due to the inflammation process. Material and Methods: This study was conducted with 30 white new zealanian rabbits under pentobarbital induced general anes thesia they were divided into two α and β-groups. Blood flow of posterior articular nerve of knee was measured by laser flow meter. α and β-gonist drugs were injected intra-arterial in the presence and absence of their antagonists. ACUTE INFLAMMATION was induced by intra-articular karaginine. Posterior articular nerve was stimulated by nerve stimulator. Results: Electrical stimulation of the posterior articular nerve resulted in vasoconstriction which was reversed to vasodilatation by phentolamine and yohimbine. The dose – response curves intra-arterial injection of α- adrenoceptor agonists showed a rank-order potency of: adrenaline= phenylephrine= clonidine. The adrenaline dose-response curve was shifted to the right by administration of antagonists with a rank-order potency of: phentolamin= yohimbine= prazosin. At this stage of the experiment there was an equal response of α1-and α2- adrenoceptors in blood vessels of the acutely inflamed rabbit KNEE JOINT. In other two groups of animals the neutrally mediated vasodilatation, which appeared after administration of phentolamine, was completely blocked by propranolol, and was reduced to about 50% by atenolol. The dose-response curves in intra –arterial injection of β- adrenoceptor agonists showed a rank-order potency of: isoprenaline> salbutamol = dobutamine. The isoprenaline dose- response curve was shifted to the right by administration of antagonists with a rank-order potency of: propranolol> atenolol. This experiment also showed an almost equal response of β1-and β 2- adrenoceptors in blood vessels of the acutely inflamed rabbit KNEE JOINT. Overall, compared to previous experiments on the normal joint in which α1-and β1- adrenoceptor responses predominated, ACUTE INFLAMMATION resulted in a shift from α2-towards α1- and from β1-towards β 2- adrenoceptors responses.Conclusion: Generally in comparison to previouse experimentas on the normal joint in which α1 and β1 receptor responses predominated, ACUTE INFLAMMATION resulted in a shift from α2 towards α1 and β1 towards β2 – receptor responses.

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APA: Copy

NAJAFIPOUR, H., & SHEYBANI, VAHID. (2002). ALTERATION IN Α AND Β ADRENOCEPTOR PROFILE OF RABBIT KNEE JOINT BLOOD VESSELS DUE TO ACUTE INFLAMMATION. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, 1(3), 146-156. SID. https://sid.ir/paper/71158/en

Vancouver: Copy

NAJAFIPOUR H., SHEYBANI VAHID. ALTERATION IN Α AND Β ADRENOCEPTOR PROFILE OF RABBIT KNEE JOINT BLOOD VESSELS DUE TO ACUTE INFLAMMATION. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES[Internet]. 2002;1(3):146-156. Available from: https://sid.ir/paper/71158/en

IEEE: Copy

H. NAJAFIPOUR, and VAHID SHEYBANI, “ALTERATION IN Α AND Β ADRENOCEPTOR PROFILE OF RABBIT KNEE JOINT BLOOD VESSELS DUE TO ACUTE INFLAMMATION,” JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, vol. 1, no. 3, pp. 146–156, 2002, [Online]. Available: https://sid.ir/paper/71158/en

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