SKIN WOUND HEALING OF CHRONIC DIABETIC RATS USING OMEGA-3 AND OMEGA- 6 FATTY ACIDS

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JAFARI NAVEH H.R.; TAGHAVI M.M.; SHARIATI M.; REZVANI A.

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Journal: JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES Year:2012 | Volume:11 | Issue:4 (45) Page(s): 355-364

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Title

SKIN WOUND HEALING OF CHRONIC DIABETIC RATS USING OMEGA-3 AND OMEGA- 6 FATTY ACIDS

Author(s)

JAFARI NAVEH H.R. | TAGHAVI M.M. | SHARIATI M. | REZVANI A. | Issue Writer Certificate

Keywords

DIABETESQ2

FISH OILQ3

CORN OILQ4

WOUND HEALINGQ3

Abstract

Background and Objectives: Scientists are trying to find ways for skin WOUND HEALING in chronic diabetic diseases. The potential role of omega-3 ( w-3) and omega-6 (w-6) fatty acids on WOUND HEALING is of interest and controversial. In this study, the effects of topical application of fish and CORN OILs containing ω-3 and ω-6 fatty acids on skin WOUND HEALING in chronic diabetic rats has been evaluated.Materials and Methods: In this intervention-experimental study, mature male rats were randomly divided into five groups (n=7). DIABETES in four groups was induced by subcutaneous injection of 50 mg/kg streptozotocin (STZ). The fifth group was served as normal or control group. In diabetic groups, one group was non- treated group (shame group), and two groups received fish and CORN OIL (FO-group and CO- group) respectively. The last diabetic group was treated with both fish and CORN OIL (FCO-group). All animals were wounded by a vertical 3 cm incision in the middle of their dorsum. Treatment was done 4 weeks after the induction of DIABETES till complete WOUND HEALING. Wound surface area was measured at 3th, 7th, 11th, 15th and 20th post-operated days. At the same times, the histological characteristics were studied by using hematoxilineosine method. Required time for full healing was also measured.Results: Our results showed that surface area of wound in FCO- group was lower than non- treated group at 11th, 15th, and 20th post- operative days significantly. Moreover the percentage of the WOUND HEALING in FCO- group was 98% at the 20th day, while this parameter in non-treated group was 70%. Histological studies showed that epidermal growth, cellular diffusion, density of collagen in FCO- group was approximately the same as the control group.Conclusion: The results showed that topical application of fish and CORN OIL together may result in an acceleration of skin WOUND HEALING in chronic diabetic rats.

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APA: Copy

JAFARI NAVEH, H.R., TAGHAVI, M.M., SHARIATI, M., & REZVANI, A.. (2012). SKIN WOUND HEALING OF CHRONIC DIABETIC RATS USING OMEGA-3 AND OMEGA- 6 FATTY ACIDS. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, 11(4 (45)), 355-364. SID. https://sid.ir/paper/71175/en

Vancouver: Copy

JAFARI NAVEH H.R., TAGHAVI M.M., SHARIATI M., REZVANI A.. SKIN WOUND HEALING OF CHRONIC DIABETIC RATS USING OMEGA-3 AND OMEGA- 6 FATTY ACIDS. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES[Internet]. 2012;11(4 (45)):355-364. Available from: https://sid.ir/paper/71175/en

IEEE: Copy

H.R. JAFARI NAVEH, M.M. TAGHAVI, M. SHARIATI, and A. REZVANI, “SKIN WOUND HEALING OF CHRONIC DIABETIC RATS USING OMEGA-3 AND OMEGA- 6 FATTY ACIDS,” JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, vol. 11, no. 4 (45), pp. 355–364, 2012, [Online]. Available: https://sid.ir/paper/71175/en

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