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Information Journal Paper

Title

CONTROLLED OVARIAN HYPERSTIMULATION WITH INTRAUTERINE INSEMINATION IS MORE SUCCESSFUL AFTER R-HCG ADMINISTRATION THAN SPONTANEOUS LH SURGE

Pages

  316-322

Abstract

 Background: The purpose of this study was to evaluate whether clinical pregnancy rate is affected by timing INTRAUTERINE INSEMINATION (IUI) according to serum LH SURGE, r-hCG trigger, or a combination of LH SURGE and r-hCG trigger in CONTROLLED OVARIAN HYPERSTIMULATION (COH) cycles for patients with a variety of INFERTILITY etiologies.Methods: The last 365 consecutive COH-IUI cycles performed at ONE Fertility Burlington in 2014 were reviewed and categorized according to method of IUI timing. Associations between categorical variables were analyzed using a combination of Chi-square and Fisher’s Exact tests, and between continuous variables using independent sample t-tests and logistic regression to a level of significance of p<0.05.Results: The overall clinical pregnancy rate in this sample was 18.1% (66.365).Administration of r-hCG prior to IUI resulted in a higher clinical pregnancy rate compared with spontaneous serum LH SURGE: 18.2%vs.5.8%, p=0.012. Patients in whom r-hCG was administered concomitantly with a serum LH SURGE had a higher clinical pregnancy than the r-hCG trigger group (30.8%vs.18.2%, p=0.004) and LH SURGE group (30.8%vs.5.8%, p<0.001). A sub-group analysis revealed that patients receiving r-FSH, rather than clomiphene or letrozole, had a significantly higher clinical pregnancy rate after r-hCG trigger as compared to the LH SURGE group (21.7% vs.2.1%, p=0.01).Conclusion: In subfertile couples undergoing COH-IUI, r-hCG administration was associated with an increased clinical pregnancy rate compared with spontaneous serum LH SURGE. When r-hCG was administered concomitantly with a serum LH SURGE, this benefit was amplified. The effect appears to be of particular importance in r-FSH-medicated cycles.

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    APA: Copy

    TAERK, EVAN, HUGHES, EDWARD, GREENBERG, CASSANDRA, NEAL, MICHAEL, AMIN, SHILPA, FAGHIH, MEHRNOOSH, & KARNIS, MEGAN. (2017). CONTROLLED OVARIAN HYPERSTIMULATION WITH INTRAUTERINE INSEMINATION IS MORE SUCCESSFUL AFTER R-HCG ADMINISTRATION THAN SPONTANEOUS LH SURGE. JOURNAL OF REPRODUCTION AND INFERTILITY, 18(3), 316-322. SID. https://sid.ir/paper/712169/en

    Vancouver: Copy

    TAERK EVAN, HUGHES EDWARD, GREENBERG CASSANDRA, NEAL MICHAEL, AMIN SHILPA, FAGHIH MEHRNOOSH, KARNIS MEGAN. CONTROLLED OVARIAN HYPERSTIMULATION WITH INTRAUTERINE INSEMINATION IS MORE SUCCESSFUL AFTER R-HCG ADMINISTRATION THAN SPONTANEOUS LH SURGE. JOURNAL OF REPRODUCTION AND INFERTILITY[Internet]. 2017;18(3):316-322. Available from: https://sid.ir/paper/712169/en

    IEEE: Copy

    EVAN TAERK, EDWARD HUGHES, CASSANDRA GREENBERG, MICHAEL NEAL, SHILPA AMIN, MEHRNOOSH FAGHIH, and MEGAN KARNIS, “CONTROLLED OVARIAN HYPERSTIMULATION WITH INTRAUTERINE INSEMINATION IS MORE SUCCESSFUL AFTER R-HCG ADMINISTRATION THAN SPONTANEOUS LH SURGE,” JOURNAL OF REPRODUCTION AND INFERTILITY, vol. 18, no. 3, pp. 316–322, 2017, [Online]. Available: https://sid.ir/paper/712169/en

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