THE EFFECTS OF VITAMIN B12 ON THE BRAIN DAMAGES CAUSED BY METHAMPHETAMINE IN MICE

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MOSHIRI MOHAMMAD; HOSSEINIYAN SEYED MOJTABA; MOALLEM SEYED ADEL; HADIZADEH FARZIN; JAFARIAN AMIR HOSSEIN; GHADIRI AMENEH; HOSEINI TOKTAM; SEIFI MAHMOUD; ETEMAD LEILA

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Journal: Iranian Journal of Basic Medical Sciences Year:2018 | Volume:21 | Issue:4 Page(s): 434-438

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Title

THE EFFECTS OF VITAMIN B12 ON THE BRAIN DAMAGES CAUSED BY METHAMPHETAMINE IN MICE

Author(s)

Keywords

CEREBRAL CORTEX

METHAMPHETAMINE

NEUROTOXICITY

STRIATUM

VITAMIN B12

Abstract

Objective (s): METHAMPHETAMINE (METH) is a powerful stimulant drug that directly affects the brain and induces neurological deficits. B12 is a water-soluble vitamin (vit) that is reported to attenuate neuronal degeneration. The goal of the present study is to investigate the effect of vitamin B12 on METH’s neurodegenerative changes.Materials and Methods: Two groups of 6 animals received METH (10 mg/kg, interaperitoneally (IP)) four times with a 2 hr interval. Thirty mins before METH administration, vit B12 (1 mg/kg) or normal saline were injected IP. Animals were sacrificed 3 days after the last administration. Caspase proteins levels were measured by Western blotting. Also, samples were examined by TUNEL assay to detect the presence of DNA fragmentation. Reduced glutathione (GSH) was also determined by the Ellman method.Results: The pathological findings showed that vit B12 attenuates the gliosis induced by METH. Vit B12 administration also significantly decreased the apoptotic index in the STRIATUM and the CEREBRAL CORTEX (P<0.001). It also reduced caspase markers compared to the control (P<0.01 and P<0.001, respectively). Interestingly, co-administration of METH and Vit B12 elevates the levels of GSH in both regions of the brain and returned it to normal levels compared to the METH group.Conclusion: The current study suggests that parenteral vit B12 at safe doses may be a promising treatment for METH-induced brain damage via inhibition of neuron apoptosis and increasing the reduced GSH level. Research focusing on the mechanisms involved in the protective responses of vit B12 can be helpful in providing a novel therapeutic agent against METH-induced NEUROTOXICITY.

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APA: Copy

MOSHIRI, MOHAMMAD, HOSSEINIYAN, SEYED MOJTABA, MOALLEM, SEYED ADEL, HADIZADEH, FARZIN, JAFARIAN, AMIR HOSSEIN, GHADIRI, AMENEH, HOSEINI, TOKTAM, ETEMAD, LEILA, & SEIFI, MAHMOUD. (2018). THE EFFECTS OF VITAMIN B₁₂ ON THE BRAIN DAMAGES CAUSED BY METHAMPHETAMINE IN MICE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(4), 434-438. SID. https://sid.ir/paper/712211/en

Vancouver: Copy

MOSHIRI MOHAMMAD, HOSSEINIYAN SEYED MOJTABA, MOALLEM SEYED ADEL, HADIZADEH FARZIN, JAFARIAN AMIR HOSSEIN, GHADIRI AMENEH, HOSEINI TOKTAM, ETEMAD LEILA, SEIFI MAHMOUD. THE EFFECTS OF VITAMIN B₁₂ ON THE BRAIN DAMAGES CAUSED BY METHAMPHETAMINE IN MICE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2018;21(4):434-438. Available from: https://sid.ir/paper/712211/en

IEEE: Copy

MOHAMMAD MOSHIRI, SEYED MOJTABA HOSSEINIYAN, SEYED ADEL MOALLEM, FARZIN HADIZADEH, AMIR HOSSEIN JAFARIAN, AMENEH GHADIRI, TOKTAM HOSEINI, LEILA ETEMAD, and MAHMOUD SEIFI, “THE EFFECTS OF VITAMIN B₁₂ ON THE BRAIN DAMAGES CAUSED BY METHAMPHETAMINE IN MICE,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 21, no. 4, pp. 434–438, 2018, [Online]. Available: https://sid.ir/paper/712211/en

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