Cinnamaldehyde improves methamphetamine-induced spatial learning and memory deficits and restores ERK signaling in the rat prefrontal cortex

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Saeed Mohammad; GHADIRI AMENEH; HADIZADEH FARZIN; ATTARANZADEH ARMIN; Alavi Mohaddeseh Sadat; ETEMAD LEILA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2018 | Volume:21 | Issue:12 Page(s): 1316-1321

Download Full-Text

View:

214

Download:

127

Cites:

Information Journal Paper

Title

Cinnamaldehyde improves methamphetamine-induced spatial learning and memory deficits and restores ERK signaling in the rat prefrontal cortex

Author(s)

Keywords

Cinnamaldehyde

ERK1/2

Learning deficit

Memory deficit

Methamphetamine

Abstract

Objective(s): Methamphetamine is a stimulant compound that penetrates readily into the central nervous system. Repeated exposure to Methamphetamine leads to damage in the dopaminergic and serotonergic axons of selected brain regions. Previous studies showed that Cinnamaldehyde improved memory impairment in animals. In the present study, we aimed to elucidate the effects of Cinnamaldehyde on Methamphetamine-induced memory impairment in rats. Materials and Methods: Male Wistar rats received Methamphetamine (10 mg/kg, intraperitoneally) for 7 days. Thirty minutes before each injection, animals were given Cinnamaldehyde (20, 40, or 80 mg/kg) or rivastigmine (1 mg/kg). The spatial learning and memory were examined using the Morris water maze test. The expression of extracellular signal-regulated kinase (ERK) phosphorylation in the frontal cortex and hippocampus was also detected by immunohistochemical method. Results: Administration of Methamphetamine increased the latency to find the platform in the learning phase, while administration of Cinnamaldehyde (40 mg/kg) or rivastigmine before Methamphetamine reversed the increased latency. Administration of Cinnamaldehyde, at the dose of 40 mg/kg with Methamphetamine, increased the time and distance traveled in the target quadrant in comparison with the amphetamine group. Moreover, the Methamphetamine and Cinnamaldehyde-treated group had higher expression of phosphorylated ERK1/2 in the prefrontal cortex in comparison with the Methamphetamine-treated animals. Conclusion: The present data demonstrated that repeated METH administration impaired cognitive performance through the ERK pathway and decreased the phosphorylation of ERK1/2 in the prefrontal cortex while administration of Cinnamaldehyde restored both effects. Accordingly, Cinnamaldehyde may be a valuable therapeutic tool for the treatment of cognitive deficits associated with Methamphetamine consumption.

Cites

Role of natural products in mitigation of toxic effects of methamphetamine: A review of in vitro and in vivo studies

References

Cite

APA: Copy

Saeed, Mohammad, GHADIRI, AMENEH, HADIZADEH, FARZIN, ATTARANZADEH, ARMIN, Alavi, Mohaddeseh Sadat, & ETEMAD, LEILA. (2018). Cinnamaldehyde improves methamphetamine-induced spatial learning and memory deficits and restores ERK signaling in the rat prefrontal cortex. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(12), 1316-1321. SID. https://sid.ir/paper/722830/en

Vancouver: Copy

Saeed Mohammad, GHADIRI AMENEH, HADIZADEH FARZIN, ATTARANZADEH ARMIN, Alavi Mohaddeseh Sadat, ETEMAD LEILA. Cinnamaldehyde improves methamphetamine-induced spatial learning and memory deficits and restores ERK signaling in the rat prefrontal cortex. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2018;21(12):1316-1321. Available from: https://sid.ir/paper/722830/en

IEEE: Copy

Mohammad Saeed, AMENEH GHADIRI, FARZIN HADIZADEH, ARMIN ATTARANZADEH, Mohaddeseh Sadat Alavi, and LEILA ETEMAD, “Cinnamaldehyde improves methamphetamine-induced spatial learning and memory deficits and restores ERK signaling in the rat prefrontal cortex,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 21, no. 12, pp. 1316–1321, 2018, [Online]. Available: https://sid.ir/paper/722830/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops