مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

METFORMIN-ATTENUATED SEPSIS-INDUCED OXIDATIVE DAMAGES: A NOVEL ROLE FOR METFORMIN

Pages

  469-475

Abstract

 Objective (s): SEPSIS can result in severe organ injury by provoking inflammatory cascades and oxidative stress. Several studies are currently underway to find a drug with anti-inflammatory effects to prevent mortality and morbidity during SEPSIS. The present study was undertaken to assess the effects of METFORMIN on oxidative stress and antioxidant status in SEPSIS induced by the Cecal Ligation and Puncture (CLP) method.Materials and Methods: Male Wistar rats were divided into 4 groups (n=10): sham, CLP, and 50 and 100 mg/ kg METFORMIN-treated CLP groups. After 12 hr, blood samples were collected and lung tissue was removed for histopathological study to detect tissue damage and degree of INFLAMMATION based on neutrophil infiltration and assay of the oxidative stress biomarkers superoxide dismutase (SOD), total antioxidant capacity (TAC), malondialdehyde (MDA), myeloperoxidase (MPO), glutathione peroxidase (GPx), and plasminogen activator inhibitor‐1 (PAI‐1).Results: The MPO activity and MDA level were decreased in the METFORMIN-treated groups (P<0.05). Moreover, the groups receiving METFORMIN showed lower INFLAMMATION scores than the CLP group (P<0.05). No significant differences in SOD, GPx, or PAI in the different groups were observed. The TAC level was reduced in the CLP group compared to the sham group (P<0.05), and interestingly, this value was reduced even further in the METFORMIN-treated groups (P<0.05 compared with the CLP group).Conclusion: It was concluded that METFORMIN protects lung tissue against SEPSIS-induced oxidative damage, and this protective effect may be more related to its anti-inflammatory and reduced neutrophil accumulation and less to its anti-oxidative properties.

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    • Cite

    APA: Copy

    GHAVIMI, HAMED, SHEIDAEI, SASAN, VAEZ, HALEH, ZOLALI, ELMIRA, Asgharian, Parina, & HAMISHEHKAR, HADI. (2018). METFORMIN-ATTENUATED SEPSIS-INDUCED OXIDATIVE DAMAGES: A NOVEL ROLE FOR METFORMIN. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(5), 469-475. SID. https://sid.ir/paper/712215/en

    Vancouver: Copy

    GHAVIMI HAMED, SHEIDAEI SASAN, VAEZ HALEH, ZOLALI ELMIRA, Asgharian Parina, HAMISHEHKAR HADI. METFORMIN-ATTENUATED SEPSIS-INDUCED OXIDATIVE DAMAGES: A NOVEL ROLE FOR METFORMIN. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2018;21(5):469-475. Available from: https://sid.ir/paper/712215/en

    IEEE: Copy

    HAMED GHAVIMI, SASAN SHEIDAEI, HALEH VAEZ, ELMIRA ZOLALI, Parina Asgharian, and HADI HAMISHEHKAR, “METFORMIN-ATTENUATED SEPSIS-INDUCED OXIDATIVE DAMAGES: A NOVEL ROLE FOR METFORMIN,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 21, no. 5, pp. 469–475, 2018, [Online]. Available: https://sid.ir/paper/712215/en

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