A Review on The Protective Effects of Metformin in Sepsis-Induced Organ Failure

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Ismail Hassan Fatima; DIDARI TINA; Khan Fazlullah; NIAZ KAMAL; MOJTAHEDZADEH MOJTABA; ABDOLLAHI MOHAMMAD

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Journal Paper

Paper Information

Journal: Cell Journal (Yakhteh) Year:2020 | Volume:21 | Issue:4 Page(s): 363-370

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Title

A Review on The Protective Effects of Metformin in Sepsis-Induced Organ Failure

Author(s)

Keywords

Adenosine Monophosphate-Activated Protein Kinase

Metformin

Multi-Organ Failure

Oxidative Stress

Sepsis

Abstract

Despite advances in Sepsis management, it remains a major intensive-care-unit (ICU) concern. From new prospective, positive effects of Metformin, such as anti-oxidant and anti-inflammatory properties are considered potentially beneficial properties for management of septic patients. This article reviewed the potential ameliorative effects of Metformin in Sepsis-induced organ failure. Information were retrieved from PubMed, Scopus, Embase, and Google Scholar. Multi-organ damage, Oxidative Stress, inflammatory cytokine stimulation, and altered circulation are hallmarks of Sepsis. Metformin exerts its effect via Adenosine Monophosphate-Activated Protein Kinase (AMPK) activation. It improves Sepsis-induced organ failure by inhibiting the production of reactive oxygen species (ROS) and pro-inflammatory cytokines, preventing the activation of transcription factors related to inflammation, decreasing neutrophil accumulation/infiltration, and also maintaining mitochondrial membrane potential. Studies reported the safety of Metformin therapeutic doses, with no evidence of lactic acidosis, in septic patients.

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APA: Copy

Ismail Hassan, Fatima, DIDARI, TINA, Khan, Fazlullah, NIAZ, KAMAL, MOJTAHEDZADEH, MOJTABA, & ABDOLLAHI, MOHAMMAD. (2020). A Review on The Protective Effects of Metformin in Sepsis-Induced Organ Failure. CELL JOURNAL (YAKHTEH), 21(4), 363-370. SID. https://sid.ir/paper/729707/en

Vancouver: Copy

Ismail Hassan Fatima, DIDARI TINA, Khan Fazlullah, NIAZ KAMAL, MOJTAHEDZADEH MOJTABA, ABDOLLAHI MOHAMMAD. A Review on The Protective Effects of Metformin in Sepsis-Induced Organ Failure. CELL JOURNAL (YAKHTEH)[Internet]. 2020;21(4):363-370. Available from: https://sid.ir/paper/729707/en

IEEE: Copy

Fatima Ismail Hassan, TINA DIDARI, Fazlullah Khan, KAMAL NIAZ, MOJTABA MOJTAHEDZADEH, and MOHAMMAD ABDOLLAHI, “A Review on The Protective Effects of Metformin in Sepsis-Induced Organ Failure,” CELL JOURNAL (YAKHTEH), vol. 21, no. 4, pp. 363–370, 2020, [Online]. Available: https://sid.ir/paper/729707/en

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