Prognostic factors in patients with acute ischemic stroke treated with intravenous tissue plasminogen activator: The first study among Iranian patients

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SADEGHI HOKMABADI ELYAR; Yazdchi Mohammad; FARHOUDI MEHDI; SADEGHI HOMAYOUN; TAHERAGHDAM ALIAKBAR; Aliyar Hannaneh; MOHAMMADI FALLAH SAHAR; ASADI ROGHAYE; Mehdizadeh Far Elham; Ghaemian Neda

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Journal: Current Journal of Neurology Year:2018 | Volume:17 | Issue:1 Page(s): 31-37

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Title

Prognostic factors in patients with acute ischemic stroke treated with intravenous tissue plasminogen activator: The first study among Iranian patients

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Keywords

Acute Stroke

Tissue Plasminogen Activator

Outcome

Risk Factors

Iran

Abstract

Background: Tissue Plasminogen Activator (tPA) has been long approved as an efficacious treatment in patients with acute ischemic stroke (AIS); however, due to some serious complications, particularly intracranial hemorrhage (ICH), many physicians are still reluctant to use it liberally. This study sought to find potential prognostic factors in patients with AIS treated with tPA. Methods: A retrospective, hospital-bases observational study was conducted. Consecutively, a total of 132 patients with AIS treated with intravenous tPA, form June 2011 to July 2015 were enrolled. Inclusion and exclusion criteria were based on updated guidelines. Probable prognostic variables were examined separately in three distinct groups; the occurrence of ICH within 24 hours after treatment, poor 3-month Outcome on the basis of modified Rankin Scale (mRS) and 3-month mortality. Results: Patients were 83 men (62. 9%) and 49 women (37. 1%) with a median age of 66 years [interquartile range (IQR)of 55-72]. Any type of hemorrhage, symptomatic hemorrhage [based on the European Cooperative Acute Stroke Study III (ECASS III) definition] within 24 hours posttreatment, poor 3-month Outcome (mRS 3-6), and 3-month mortality were documented in 10. 6%, 4. 5%, 53. 2%, and 23. 6% of patients, respectively. Increased baseline blood glucose was a significant but dependent predictor of hemorrhage within the first 24 hours posttreatment. Dependent predictors of a 3-month poor Outcome were high age, the National Institutes of Health Stroke Scale (NIHSS) at baseline, decreased admitting glomerular filtration rate (GFR), and the presence of atrial fibrillation (AF) rhythm, and ICH within 24 hours posttreatment. Only age [Odds ratio (OR) adjusted 1. 05] and initial NIHSS (OR adjusted 1. 23), however, were recognized as the independent variables in this regard. The only independent predictor of 3-month mortality was the initial NIHSS (OR adjusted 1. 18). Conclusion: According to the findings of the present study, advanced age and high baseline NIHSS are two independent prognostic factors in patients with AIS treated with tPA.

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APA: Copy

SADEGHI HOKMABADI, ELYAR, Yazdchi, Mohammad, FARHOUDI, MEHDI, SADEGHI, HOMAYOUN, TAHERAGHDAM, ALIAKBAR, Aliyar, Hannaneh, MOHAMMADI FALLAH, SAHAR, ASADI, ROGHAYE, Mehdizadeh Far, Elham, & Ghaemian, Neda. (2018). Prognostic factors in patients with acute ischemic stroke treated with intravenous tissue plasminogen activator: The first study among Iranian patients. CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY), 17(1), 31-37. SID. https://sid.ir/paper/712352/en

Vancouver: Copy

SADEGHI HOKMABADI ELYAR, Yazdchi Mohammad, FARHOUDI MEHDI, SADEGHI HOMAYOUN, TAHERAGHDAM ALIAKBAR, Aliyar Hannaneh, MOHAMMADI FALLAH SAHAR, ASADI ROGHAYE, Mehdizadeh Far Elham, Ghaemian Neda. Prognostic factors in patients with acute ischemic stroke treated with intravenous tissue plasminogen activator: The first study among Iranian patients. CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY)[Internet]. 2018;17(1):31-37. Available from: https://sid.ir/paper/712352/en

IEEE: Copy

ELYAR SADEGHI HOKMABADI, Mohammad Yazdchi, MEHDI FARHOUDI, HOMAYOUN SADEGHI, ALIAKBAR TAHERAGHDAM, Hannaneh Aliyar, SAHAR MOHAMMADI FALLAH, ROGHAYE ASADI, Elham Mehdizadeh Far, and Neda Ghaemian, “Prognostic factors in patients with acute ischemic stroke treated with intravenous tissue plasminogen activator: The first study among Iranian patients,” CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY), vol. 17, no. 1, pp. 31–37, 2018, [Online]. Available: https://sid.ir/paper/712352/en

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