The Role of Adrenergic Receptors on Neural Excitability and Synaptic Plasticity: A Narrative Review

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Ahmadirad n.; ZARE M.; JANAHMADI M.; FATHOLLAHI Y.; SHOJAEI A.; MIRNAJAFIZADEH S.J.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES Year:2020 | Volume:18 | Issue:10 Page(s): 1049-1064

Download Full-Text

Persian Verion

View:

1,493

Download:

Cites:

Information Journal Paper

Title

The Role of Adrenergic Receptors on Neural Excitability and Synaptic Plasticity: A Narrative Review

Author(s)

Keywords

Alpha-adrenergic receptorQ1

Beta-adrenergic receptorQ1

SeizureQ3

Neural excitabilityQ1

Synaptic plasticityQ1

Abstract

Adrenergic receptors have an important role in Neural excitability and Synaptic plasticity. Despite a lot of studies on these receptors, their exact role in brain disorders accompanied with hyperexcitability has not been determined. There are also controversies on their role in Synaptic plasticity. In this review article, the important studies done in this regard have been reviewed to achieve a good summary of the effects of these receptors on neuronal excitability and Synaptic plasticity. Despite the controversial results that have been reported in previous studies, it seems that alpha-1 and alpha-2 receptors decrease the neuronal excitability during Seizure. Alpha 1A receptors, by acting on inhibitory interaneurons and increasing the GABAergic activity, are primarily responsible for the inhibitory function of alpha-1 receptors in reducing neuronal excitability, while beta-1 receptors may increase the excitability by increasing glutamate release. Moreover, alpha-1 receptor activity mostly induces long-term weakening in synapses. On the other hand, Beta-adrenergic receptors increase the neuronal excitability and induce long-term potentiation through increasing both the glutamate release and the neurogenesis.

Cites

No record.

References

Cite

APA: Copy

Ahmadirad, n., ZARE, M., JANAHMADI, M., FATHOLLAHI, Y., SHOJAEI, A., & MIRNAJAFIZADEH, S.J.. (2020). The Role of Adrenergic Receptors on Neural Excitability and Synaptic Plasticity: A Narrative Review. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, 18(10 ), 1049-1064. SID. https://sid.ir/paper/71269/en

Vancouver: Copy

Ahmadirad n., ZARE M., JANAHMADI M., FATHOLLAHI Y., SHOJAEI A., MIRNAJAFIZADEH S.J.. The Role of Adrenergic Receptors on Neural Excitability and Synaptic Plasticity: A Narrative Review. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES[Internet]. 2020;18(10 ):1049-1064. Available from: https://sid.ir/paper/71269/en

IEEE: Copy

n. Ahmadirad, M. ZARE, M. JANAHMADI, Y. FATHOLLAHI, A. SHOJAEI, and S.J. MIRNAJAFIZADEH, “The Role of Adrenergic Receptors on Neural Excitability and Synaptic Plasticity: A Narrative Review,” JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, vol. 18, no. 10 , pp. 1049–1064, 2020, [Online]. Available: https://sid.ir/paper/71269/en

Related Journal Papers