Simultaneous Effect of High Intensity Interval Training and Decellularized Amniotic Membrane Fluid Scaffold on Gene Expression of Cell Proliferation Factors of Satellite Cells in the Volumetric Muscle Loss Injury in the Tibialis Anterior of Rats: An Experimental Study

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Izadi m.r.; HABIBI A.; KHODABANDEH Z.; NIKBAKHT M.

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Journal: JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES Year:2019 | Volume:18 | Issue:9 Page(s): 875-888

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Title

Simultaneous Effect of High Intensity Interval Training and Decellularized Amniotic Membrane Fluid Scaffold on Gene Expression of Cell Proliferation Factors of Satellite Cells in the Volumetric Muscle Loss Injury in the Tibialis Anterior of Rats: An Experimental Study

Author(s)

Izadi m.r. | HABIBI A. | KHODABANDEH Z. | NIKBAKHT M. | Issue Writer Certificate

Keywords

High-intensity interval trainingQ1

Satellite cellsQ1

Tissue engineeringQ2

RatsQ2

Abstract

Background and Objectives: The purpose of the present study was to determine the simultaneous effect of high intensity interval training and decellularized amniotic membrane scaffold on gene expression of cell proliferation factors of Satellite cells in the volumetric muscle loss injury in the tibialis anterior of Rats. Materials and Methods: In this experimental study, after preparation of human amniotic membrane and its decellularization process, volumetric muscle loss (VML) on the tibialis anterior muscle was performed on 24 Rats. The Rats were divided into two groups of 12 according to receiving and not receiving amniotic membrane scaffold. Each group was then divided into High-intensity interval training (HIIT) and untreated groups. Real-time PCR technique was used to examine the gene expression of the three PAX7, MyoD1 and Myogenin genes. Results: There was a significant difference in the gene expression of PAX7 in the HIIT group with scaffolds compared to the non-scaffold training group (p=0. 004) and the other two groups (p<0. 001). In the gene expression of MyoD1, the HIIT group was significantly different from the sedentary group with scaffold (p=0. 050) and the two groups without scaffold (p<0. 001), respectively. In the gene expression of Myogenin, the HIIT group was significantly different from the sedentary group with scaffold (p=0. 031) and the two groups without scaffold (p<0. 001), respectively. Conclusion: The results showed that the combination of HIIT and insert of decellularized amniotic membrane scaffold increases the gene expression of PAX7, MyoD1 and Myogenin and may be effective in the regeneration of volumetric muscle loss injury.

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APA: Copy

Izadi, m.r., HABIBI, A., KHODABANDEH, Z., & NIKBAKHT, M.. (2019). Simultaneous Effect of High Intensity Interval Training and Decellularized Amniotic Membrane Fluid Scaffold on Gene Expression of Cell Proliferation Factors of Satellite Cells in the Volumetric Muscle Loss Injury in the Tibialis Anterior of Rats: An Experimental Study. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, 18(9 ), 875-888. SID. https://sid.ir/paper/71320/en

Vancouver: Copy

Izadi m.r., HABIBI A., KHODABANDEH Z., NIKBAKHT M.. Simultaneous Effect of High Intensity Interval Training and Decellularized Amniotic Membrane Fluid Scaffold on Gene Expression of Cell Proliferation Factors of Satellite Cells in the Volumetric Muscle Loss Injury in the Tibialis Anterior of Rats: An Experimental Study. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES[Internet]. 2019;18(9 ):875-888. Available from: https://sid.ir/paper/71320/en

IEEE: Copy

m.r. Izadi, A. HABIBI, Z. KHODABANDEH, and M. NIKBAKHT, “Simultaneous Effect of High Intensity Interval Training and Decellularized Amniotic Membrane Fluid Scaffold on Gene Expression of Cell Proliferation Factors of Satellite Cells in the Volumetric Muscle Loss Injury in the Tibialis Anterior of Rats: An Experimental Study,” JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, vol. 18, no. 9 , pp. 875–888, 2019, [Online]. Available: https://sid.ir/paper/71320/en

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