THE EFFECT OF 8 WEEKS HIGH-INTENSITY INTERVAL TRAINING ON MYOSTATIN AND FOLLISTATIN GENE EXPRESSION IN GASTROCNEMIUS MUSCLE OF THE RATS

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BIGLARI SOHEIL; GAEINI ABBASALI; KORDI MOHAMMAD REZA; GHARDASHI AFOUSI ALIREZA

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Journal: Journal of Arak University Medical Sciences Year:2018 | Volume:21 | Issue:1 (130) Page(s): 1-10

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Title

THE EFFECT OF 8 WEEKS HIGH-INTENSITY INTERVAL TRAINING ON MYOSTATIN AND FOLLISTATIN GENE EXPRESSION IN GASTROCNEMIUS MUSCLE OF THE RATS

Author(s)

BIGLARI SOHEIL | GAEINI ABBASALI | KORDI MOHAMMAD REZA | GHARDASHI AFOUSI ALIREZA | Issue Writer Certificate

Keywords

FOLLISTATINQ1

HIITQ1

HYPERTROPHYQ1

MYOSTATINQ1

REAL TIME-PCRQ1

Abstract

Background: The purpose of the present study is to investigate the effect of 8 weeks High-intensity Interval Training (HIIT) on the expression of two muscle growth regulating genes (myostatin and FOLLISTATIN) in gastrocnemius muscle of healthy male rats.Materials and Methods: 16 male Wistar rats were randomly divided into two groups in the same number: control and HIIT. HIIT program was underwent 40 min each session, three sessions in a week for eight weeks. Each exercise training session consisted of 5 min warm-up and cool-down at 40-50% VO2max, 30 min interval running including 4 min high-intensity (85-90% VO2max) and 2 min active recovery (at 50-60% VO2max). Rats in control group did not do any exercise training program.48 h after the last training session, rats` gastrocnemius muscle was extracted and the expression of MYOSTATIN and FOLLISTATIN genes was determined by REAL TIME-PCR. For statistical data analysis, independent t-test was used.Results: The expression of MYOSTATIN was significantly reduced 68% in HIIT group in comparison with the control group (p<0.05). However, there was no significant difference in FOLLISTATIN expression in HIIT group compared to the control group (p>0.05). Gastrocnemius muscle weight was significantly increased 23% in the HIIT group compared to the control group (p<0.05).Conclusion: Results indicated that HIIT lead to significant reduction in the expression of MYOSTATIN gene and increase in the weight of gastrocnemius muscle in rats.

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APA: Copy

BIGLARI, SOHEIL, GAEINI, ABBASALI, KORDI, MOHAMMAD REZA, & GHARDASHI AFOUSI, ALIREZA. (2018). THE EFFECT OF 8 WEEKS HIGH-INTENSITY INTERVAL TRAINING ON MYOSTATIN AND FOLLISTATIN GENE EXPRESSION IN GASTROCNEMIUS MUSCLE OF THE RATS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 21(1 (130) ), 1-10. SID. https://sid.ir/paper/69706/en

Vancouver: Copy

BIGLARI SOHEIL, GAEINI ABBASALI, KORDI MOHAMMAD REZA, GHARDASHI AFOUSI ALIREZA. THE EFFECT OF 8 WEEKS HIGH-INTENSITY INTERVAL TRAINING ON MYOSTATIN AND FOLLISTATIN GENE EXPRESSION IN GASTROCNEMIUS MUSCLE OF THE RATS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2018;21(1 (130) ):1-10. Available from: https://sid.ir/paper/69706/en

IEEE: Copy

SOHEIL BIGLARI, ABBASALI GAEINI, MOHAMMAD REZA KORDI, and ALIREZA GHARDASHI AFOUSI, “THE EFFECT OF 8 WEEKS HIGH-INTENSITY INTERVAL TRAINING ON MYOSTATIN AND FOLLISTATIN GENE EXPRESSION IN GASTROCNEMIUS MUSCLE OF THE RATS,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 21, no. 1 (130) , pp. 1–10, 2018, [Online]. Available: https://sid.ir/paper/69706/en

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