DEVELOPMENT AND ASSESSMENT OF 153SM-ZOLEDRONATE COMPLEX AS A POSSIBLE BONE PAIN PALLIATIVE AGENT

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NIKZAD MIRSAEED; JALILIAN AMIR REZA; SHIRVANI ARANI SIMINDOKHT; ARABIEH MASOOD; SHANESAZZADEH SAEED; GOLCHOOBIAN HAMID

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Journal: IRANIAN JOURNAL OF NUCLEAR MEDICINE Year:2017 | Volume:25 | Issue:2 (SERIAL NUMBER 49) Page(s): 81-91

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Title

DEVELOPMENT AND ASSESSMENT OF 153SM-ZOLEDRONATE COMPLEX AS A POSSIBLE BONE PAIN PALLIATIVE AGENT

Author(s)

Keywords

153SM

ZOLEDRONIC ACID

BIODISTRIBUTION

DOSIMETRY

BONE PAIN PALLIATION

Abstract

Introduction: In this work, 153Sm-zoledronate (153Sm-ZLD) was studied using computational chemistry methods and prepared for possible use in BONE PAIN PALLIATION therapy.Methods: The Sm (ZLD) 2.7H2O complex was synthesized and characterized in solid state using computational chemistry methods followed by153Sm-ZLD complex production, stablity, hydroxyapatite (HA) tests and also biodictribution studies in animals were studied and used for absorbed dose determination in critical organs.Results: The Sm (ZLD) 2.7H2O complex was synthesized and characterized in solid state and computational chemistry methods showed that 1: 1, 1: 2 and 1: 3 complex formation are possible in aqueous solution.153Sm-ZLD complex was prepared with> 99% radiochemical purity (ITLC, HPLC) and specific activity of 4.4 GBq/mmol. It was stable for 24h with>95% binding to HA with accumulation in rat bones and kidneys. Absorbed dose showed kidney and osteogenic tissue as critical organs.Conclusion: The 153Sm-ZLD complex data were compared to 153Sm-EDTMP and 153Sm-BPAMD.

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APA: Copy

NIKZAD, MIRSAEED, JALILIAN, AMIR REZA, SHIRVANI ARANI, SIMINDOKHT, ARABIEH, MASOOD, SHANESAZZADEH, SAEED, & GOLCHOOBIAN, HAMID. (2017). DEVELOPMENT AND ASSESSMENT OF ¹⁵³SM-ZOLEDRONATE COMPLEX AS A POSSIBLE BONE PAIN PALLIATIVE AGENT. IRANIAN JOURNAL OF NUCLEAR MEDICINE, 25(2 (SERIAL NUMBER 49)), 81-91. SID. https://sid.ir/paper/713792/en

Vancouver: Copy

NIKZAD MIRSAEED, JALILIAN AMIR REZA, SHIRVANI ARANI SIMINDOKHT, ARABIEH MASOOD, SHANESAZZADEH SAEED, GOLCHOOBIAN HAMID. DEVELOPMENT AND ASSESSMENT OF ¹⁵³SM-ZOLEDRONATE COMPLEX AS A POSSIBLE BONE PAIN PALLIATIVE AGENT. IRANIAN JOURNAL OF NUCLEAR MEDICINE[Internet]. 2017;25(2 (SERIAL NUMBER 49)):81-91. Available from: https://sid.ir/paper/713792/en

IEEE: Copy

MIRSAEED NIKZAD, AMIR REZA JALILIAN, SIMINDOKHT SHIRVANI ARANI, MASOOD ARABIEH, SAEED SHANESAZZADEH, and HAMID GOLCHOOBIAN, “DEVELOPMENT AND ASSESSMENT OF ¹⁵³SM-ZOLEDRONATE COMPLEX AS A POSSIBLE BONE PAIN PALLIATIVE AGENT,” IRANIAN JOURNAL OF NUCLEAR MEDICINE, vol. 25, no. 2 (SERIAL NUMBER 49), pp. 81–91, 2017, [Online]. Available: https://sid.ir/paper/713792/en

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