TYPE 1 DIABETES MELLITUS: CELLULAR AND MOLECULAR PATHOPHYSIOLOGY AT A GLANCE

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SABERZADEH ARDESTANI BAHAR; KARAMZADEH RAZIEH; BASIRI MOHSEN; Hajizadeh Saffar Ensiyeh; FARHADI AISAN; JAMES SHAPIRO A.M.; TAHAMTANI YASER; BAHARVAND HOSSEIN

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Journal: Cell Journal (Yakhteh) Year:2018 | Volume:20 | Issue:3 Page(s): 294-311

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Title

TYPE 1 DIABETES MELLITUS: CELLULAR AND MOLECULAR PATHOPHYSIOLOGY AT A GLANCE

Author(s)

Keywords

DIABETES COMPLICATION

ENVIRONMENT

ETIOLOGY

GENETIC

TYPE 1 DIABETES MELLITUS

Abstract

Type 1 diabetes mellitus (T1DM) is a disease where destruction of the insulin producing pancreatic beta-cells leads to increased blood sugar levels. Both GENETIC and ENVIRONMENTal factors play a part in the development of T1DM. Currently, numerous loci are specified to be the responsible GENETIC factors for T1DM; however, the mechanisms of only a few of these genes are known. Although several ENVIRONMENTal factors are presumed responsible for progression of T1DM, to date, most of their mechanisms remain undiscovered. After several years of hyperglycemia, late onsets of macrovascular (e.g., cardiovascular) and microvascular (e.g., neurological, ophthalmological, and renal) complications may occur. This review and accompanying figures provides an overview of the etiological factors for T1DM, its pathogenesis at the cellular level, and attributed complications.

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APA: Copy

SABERZADEH ARDESTANI, BAHAR, KARAMZADEH, RAZIEH, BASIRI, MOHSEN, Hajizadeh Saffar, Ensiyeh, FARHADI, AISAN, JAMES SHAPIRO, A.M., TAHAMTANI, YASER, & BAHARVAND, HOSSEIN. (2018). TYPE 1 DIABETES MELLITUS: CELLULAR AND MOLECULAR PATHOPHYSIOLOGY AT A GLANCE. CELL JOURNAL (YAKHTEH), 20(3), 294-311. SID. https://sid.ir/paper/714189/en

Vancouver: Copy

SABERZADEH ARDESTANI BAHAR, KARAMZADEH RAZIEH, BASIRI MOHSEN, Hajizadeh Saffar Ensiyeh, FARHADI AISAN, JAMES SHAPIRO A.M., TAHAMTANI YASER, BAHARVAND HOSSEIN. TYPE 1 DIABETES MELLITUS: CELLULAR AND MOLECULAR PATHOPHYSIOLOGY AT A GLANCE. CELL JOURNAL (YAKHTEH)[Internet]. 2018;20(3):294-311. Available from: https://sid.ir/paper/714189/en

IEEE: Copy

BAHAR SABERZADEH ARDESTANI, RAZIEH KARAMZADEH, MOHSEN BASIRI, Ensiyeh Hajizadeh Saffar, AISAN FARHADI, A.M. JAMES SHAPIRO, YASER TAHAMTANI, and HOSSEIN BAHARVAND, “TYPE 1 DIABETES MELLITUS: CELLULAR AND MOLECULAR PATHOPHYSIOLOGY AT A GLANCE,” CELL JOURNAL (YAKHTEH), vol. 20, no. 3, pp. 294–311, 2018, [Online]. Available: https://sid.ir/paper/714189/en

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