CALMODULIN POTENTIATES THE ANTINOCICEPTIVE EFFECTS OF MORPHINE IN RATS

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AZARANG AFROUZ; SHAMSIZADEH ALI; SHEYBANI VAHID; AZIZ ELAHI SAEID; SEPEHRI GH.R.; REZVANI M.E.; MAHMOUDI MAHDI

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Journal: JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES Year:2009 | Volume:8 | Issue:1 (30) Page(s): 11-18

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Title

CALMODULIN POTENTIATES THE ANTINOCICEPTIVE EFFECTS OF MORPHINE IN RATS

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Keywords

CALMODULINQ3

TOLERANCEQ3

MORPHINEQ2

W-7Q3

Abstract

Background and Objectives: CALMODULIN is involved in signaling pathways of opioid receptors. The present study was performed to determine the effect of chronic intracerebroventricular (ICV) administration of W-7, a specific CALMODULIN inhibitor, on the development of MORPHINE TOLERANCE.Materials and Methods: This experimental study was carried out on 75 male wistar rats weighing 200-250 g. The cannula was placed in the lateral ventricle of rat's brain according to the Paxinos and Watson atlas using the stereotaxic instrument. Rats were allowed a 7 day recovery period after the surgery for implantation of the cannula. MORPHINE was injected intraperitoneally based on a daily dose of 15mg/kg for 8 days. The development of TOLERANCE to analgesic effects of MORPHINE was measured on days 1, 3, 5 and 8 by Tail-Flick test. W-7 (0.25, 0.5 and 1micromol/rat) was injected as ICV each day 10 minutes prior the MORPHINE administration. On days that Tail-Flick test was performed W-7 was administered after the test.Results: Chronic administration of MORPHINE alone for 8 days induced TOLERANCE to its antinociceptive effect. ICV administration of W-7 in dose of 0.5 and 1 micomol/rat could prevent the development of MORPHINE TOLERANCE. However administration of W-7 in dose of 0.25 micomol/rat could not prevent the development of MORPHINE TOLERANCE.Conclusion: Chronic ICV administration of W-7 (a specific CALMODULIN inhibitor) inhibited the development of MORPHINE TOLERANCE. These results indicate that CALMODULIN and CALMODULIN- dependent pathways may play a role in the MORPHINE TOLERANCE process.

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APA: Copy

AZARANG, AFROUZ, SHAMSIZADEH, ALI, SHEYBANI, VAHID, AZIZ ELAHI, SAEID, SEPEHRI, GH.R., REZVANI, M.E., & MAHMOUDI, MAHDI. (2009). CALMODULIN POTENTIATES THE ANTINOCICEPTIVE EFFECTS OF MORPHINE IN RATS. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, 8(1 (30)), 11-18. SID. https://sid.ir/paper/71423/en

Vancouver: Copy

AZARANG AFROUZ, SHAMSIZADEH ALI, SHEYBANI VAHID, AZIZ ELAHI SAEID, SEPEHRI GH.R., REZVANI M.E., MAHMOUDI MAHDI. CALMODULIN POTENTIATES THE ANTINOCICEPTIVE EFFECTS OF MORPHINE IN RATS. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES[Internet]. 2009;8(1 (30)):11-18. Available from: https://sid.ir/paper/71423/en

IEEE: Copy

AFROUZ AZARANG, ALI SHAMSIZADEH, VAHID SHEYBANI, SAEID AZIZ ELAHI, GH.R. SEPEHRI, M.E. REZVANI, and MAHDI MAHMOUDI, “CALMODULIN POTENTIATES THE ANTINOCICEPTIVE EFFECTS OF MORPHINE IN RATS,” JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, vol. 8, no. 1 (30), pp. 11–18, 2009, [Online]. Available: https://sid.ir/paper/71423/en

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