THE ROLE OF CALMODULIN INHIBITION IN INTRATHECAL TRIFLUOPERAZINE-INDUCED ANALESIA

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GOLBIDI S.; GHAFGHAZI T.; HAJ HASHEMI V.A.; MORIUCHI H.

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Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2003 | Volume:7 | Issue:Supplement 2 Page(s): 156-161

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Title

THE ROLE OF CALMODULIN INHIBITION IN INTRATHECAL TRIFLUOPERAZINE-INDUCED ANALESIA

Author(s)

GOLBIDI S. | GHAFGHAZI T. | HAJ HASHEMI V.A. | MORIUCHI H. | Issue Writer Certificate

Keywords

CALMODULIN INHIBITIONQ4

SUBARACHNOID SPACEQ4

TRIFLUOPERAZINEQ4

ANTINOCICEPTIONQ4

Abstract

Introduction. Antipsychotic drugs are known to produce analgesic effects, but the mechanisms are not well established. In addition, some calmodulin inhibitors are reported to produce antinociceptive effects. Among antipsychotic drugs, TRIFLUOPERAZINE is one of the most potent calmodulin inhibitors. We examined which of the known properties of this drug, including anti-dopaminergic, anti-cholinergic, anti-adrenergic, anti-histaminic, and CALMODULIN INHIBITION are involved in its anlgesic effect.Methods. The effects of varios agents on formalin test were evaluated 15 minutes after drug administration. All tested agents were injected through an intrathecal catheter. Since antinociceptive measures with formalin test are based on motor function, we also used rotarod test to quantify motor side effects of the drugs. Results and Discussion. Intrathecal TRIFLUOPERAZINE showed antinociceptive effects in a biphasic fashion i.e., analgesia at relatively low doses (1, 10 µg/rat) and hyperalgesia at the higher dose (100 µg/rat). No analgesic effects were observed after intrathecal injection of sulpiride, atropine, phentolamine and brompheniramine. Meanwhile, intrathecal calmidazolium induced a dose dependent analgesia (10, 50, 250 µg/rat). Low doses of histamine (1 µg/rat), physostigmine (1 µg/rat), bromocriptine (1 µg/rat) and norepinephrine (1 µg/rat) did not affect TRIFLUOPERAZINE-induced analgesia. Calcium attenuated antinociceptive effect of TRIFLUOPERAZINE and inhibited analgesic effect of calmidazolium. Finally, naloxone decreased TRIFLUOPERAZINE-induced ANTINOCICEPTION but did not have any effect on calmidazolium-induced analgesia. We concluded that CALMODULIN INHIBITION may be involved in the analgesia produced by TRIFLUOPERAZINE. With increasing doses of TRIFLUOPERAZINE, algesic effect seems to overcome the analgesic effect. It is also suggested that the opioidergic system does not connect with "CALMODULIN INHIBITION"-induced analgesia even though this system has partial role in TRIFLUOPERAZINE-induced analgesia.

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APA: Copy

GOLBIDI, S., GHAFGHAZI, T., HAJ HASHEMI, V.A., & MORIUCHI, H.. (2003). THE ROLE OF CALMODULIN INHIBITION IN INTRATHECAL TRIFLUOPERAZINE-INDUCED ANALESIA. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 7(Supplement 2), 156-161. SID. https://sid.ir/paper/26682/en

Vancouver: Copy

GOLBIDI S., GHAFGHAZI T., HAJ HASHEMI V.A., MORIUCHI H.. THE ROLE OF CALMODULIN INHIBITION IN INTRATHECAL TRIFLUOPERAZINE-INDUCED ANALESIA. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2003;7(Supplement 2):156-161. Available from: https://sid.ir/paper/26682/en

IEEE: Copy

S. GOLBIDI, T. GHAFGHAZI, V.A. HAJ HASHEMI, and H. MORIUCHI, “THE ROLE OF CALMODULIN INHIBITION IN INTRATHECAL TRIFLUOPERAZINE-INDUCED ANALESIA,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 7, no. Supplement 2, pp. 156–161, 2003, [Online]. Available: https://sid.ir/paper/26682/en

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