DEEP BRAIN STIMULATION IN A RAT MODEL OF POST-TRAUMATIC STRESS DISORDER MODIFIES FOREBRAIN NEURONAL ACTIVITY AND SERUM CORTICOSTERONE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MOKHTARI HASHTJINI MINA; Pirzad Jahromi Gila; Sadr Seyed Shahabeddin; MEFTAHI GHOLAM HOSSEIN; Hatef Boshra; JAVIDNAZAR DANIAL

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2018 | Volume:21 | Issue:4 Page(s): 370-375

Download Full-Text

View:

260

Download:

273

Cites:

Information Journal Paper

Title

DEEP BRAIN STIMULATION IN A RAT MODEL OF POST-TRAUMATIC STRESS DISORDER MODIFIES FOREBRAIN NEURONAL ACTIVITY AND SERUM CORTICOSTERONE

Author(s)

Keywords

AMYGDALA

ANXIETY BEHAVIOR

CORTICOSTERONE

C-FOS

DEEP BRAIN STIMULATION

FREEZING BEHAVIOR

POST-TRAUMATIC STRESS DISORDER

Abstract

Objective (s): POST-TRAUMATIC STRESS DISORDER (PTSD), one of the most devastating kinds of anxiety disorders, is the consequence of a traumatic event followed by intense fear. In rats with contextual fear conditioning (CFC), a model of PTSD caused by CFC (electrical foot shock chamber), DEEP BRAIN STIMULATION (DBS) alleviates CFC abnormalities.Materials and Methods: Forty Male Wistar rats (220–250 g) were divided into 5 groups (n=8) and underwent stereotactic surgery to implant electrodes in the right basolateral nucleus of the AMYGDALA (BLn). After 7 days, some animals received a foot shock, followed by another 7-day treatment schedule (DBS treatment). Next, FREEZING BEHAVIOR was measured as a predicted response in the absence of the foot shock (re-exposure time). Blood serum CORTICOSTERONE levels and AMYGDALA C-FOS protein expression were assessed using Enzymelinked immunosorbent assay (ELISA) and Western blot, respectively. Furthermore, FREEZING BEHAVIORs by re-exposure time test and general anxiety by elevated plus-maze (EPM) were evaluated.Results: PTSD decreased serum CORTICOSTERONE levels and increased both AMYGDALA C-FOS expression and FREEZING BEHAVIORs. Therefore, DBS treatment significantly (P<0.001) enhanced serum CORTICOSTERONE levels and could significantly (P<0.001) reduce both C-FOS protein expression and FREEZING BEHAVIORs’ duration. However, DBS treatment has no effect on the general anxiety in PTSD rats.Conclusion: We argue that these outcomes might demonstrate the mechanism of DBS treatment, a complete therapeutic strategy, in PTSD patients.

Cites

Comparison of the Effects of Deep Brain Stimulation of the Prelimbic Cortex and Basolateral Amygdala for Facilitation of Extinction Process of Conditioned Fear

References

No record.

Cite

APA: Copy

MOKHTARI HASHTJINI, MINA, Pirzad Jahromi, Gila, Sadr, Seyed Shahabeddin, MEFTAHI, GHOLAM HOSSEIN, Hatef, Boshra, & JAVIDNAZAR, DANIAL. (2018). DEEP BRAIN STIMULATION IN A RAT MODEL OF POST-TRAUMATIC STRESS DISORDER MODIFIES FOREBRAIN NEURONAL ACTIVITY AND SERUM CORTICOSTERONE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(4), 370-375. SID. https://sid.ir/paper/715003/en

Vancouver: Copy

MOKHTARI HASHTJINI MINA, Pirzad Jahromi Gila, Sadr Seyed Shahabeddin, MEFTAHI GHOLAM HOSSEIN, Hatef Boshra, JAVIDNAZAR DANIAL. DEEP BRAIN STIMULATION IN A RAT MODEL OF POST-TRAUMATIC STRESS DISORDER MODIFIES FOREBRAIN NEURONAL ACTIVITY AND SERUM CORTICOSTERONE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2018;21(4):370-375. Available from: https://sid.ir/paper/715003/en

IEEE: Copy

MINA MOKHTARI HASHTJINI, Gila Pirzad Jahromi, Seyed Shahabeddin Sadr, GHOLAM HOSSEIN MEFTAHI, Boshra Hatef, and DANIAL JAVIDNAZAR, “DEEP BRAIN STIMULATION IN A RAT MODEL OF POST-TRAUMATIC STRESS DISORDER MODIFIES FOREBRAIN NEURONAL ACTIVITY AND SERUM CORTICOSTERONE,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 21, no. 4, pp. 370–375, 2018, [Online]. Available: https://sid.ir/paper/715003/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops