MIR-9-5P AND MIR-106A-5P DYSREGULATED IN CD4+ T-CELLS OF MULTIPLE SCLEROSIS PATIENTS AND TARGETED ESSENTIAL FACTORS OF T HELPER17/REGULATORY T-CELLS DIFFERENTIATION

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MAJD MARYAM; HOSSEINI AREF; GHAEDI KAMRAN; KIANI ESFAHANI ABBAS; TANHAEI SOMAYEH; SHIRALIAN ESFAHANI HANIEH; RAHNAMAEE SEYED YAHYA; MOWLA SEYED JAVAD; NASRESFAHANI MOHAMMAD HOSSEIN

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2018 | Volume:21 | Issue:3 Page(s): 277-283

Download Full-Text

View:

275

Download:

409

Cites:

Information Journal Paper

Title

MIR-9-5P AND MIR-106A-5P DYSREGULATED IN CD4+ T-CELLS OF MULTIPLE SCLEROSIS PATIENTS AND TARGETED ESSENTIAL FACTORS OF T HELPER17/REGULATORY T-CELLS DIFFERENTIATION

Author(s)

Keywords

MICRORNA

MIR-106A-5P

MIR-9-5P

MULTIPLE SCLEROSIS

TH17

Abstract

Objective (s): MULTIPLE SCLEROSIS (MS) is considered as a chronic type of an inflammatory disease characterized by loss of myelin of CNS. Recent evidence indicates that Interleukin 17 (IL-17)-producing T helper cells (Th17 cells) population are increased and regulatory T cells (Treg cells) are decreased in MS. Despite extensive research in understanding the mechanism of TH17 and Treg differentiation, the role of MICRORNAs in MS is not completely understood. Thereby, as a step closer, we analyzed the expression profile of MIR-9-5P and MIR-106A-5P, and protein level of retinoic acid receptor (RAR)-related orphan receptor C (RORC; TH17 master transcription factor) as direct target of MIR-106A-5P and forkhead box P3 (FOXP3; Treg master transcription factor) as indirect target of MIR-9-5P in CD4+ T cells in two groups of relapsing and remitting in our relapsing-remitting MS (RR-MS) patients.Materials and Methods: Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was utilized to assess the expression of miRNAs and mRNAs, in 40 RR-MS patients and 11 healthy individuals. Thus, FOXP3 and RAR-related orphan receptor gt (RORgt) was assessed in CD4+T-cells by flow cytometry. We also investigated the role of these miRNAs in TH17/Treg differentiation pathway through bioinformatics tools.Results: An up-regulation of MIR-9-5P and down-regulation of MIR-106A-5P in relapsing phase of MS patients were observed compared to healthy controls. RORC and FOXP3 were up-regulated in relapsing and remitting phases of MS, respectively.Conclusion: Expression pattern of MIR-9-5P and MIR-106A-5P and their targets suggest a possible inducing role of MIR-9-5P and suppressing role of MIR-106A-5P in differentiation pathway of TH17 cells during MS pathogenesis.

Cites

No record.

References

No record.

Cite

APA: Copy

MAJD, MARYAM, HOSSEINI, AREF, GHAEDI, KAMRAN, KIANI ESFAHANI, ABBAS, TANHAEI, SOMAYEH, SHIRALIAN ESFAHANI, HANIEH, RAHNAMAEE, SEYED YAHYA, MOWLA, SEYED JAVAD, & NASRESFAHANI, MOHAMMAD HOSSEIN. (2018). MIR-9-5P AND MIR-106A-5P DYSREGULATED IN CD4⁺ T-CELLS OF MULTIPLE SCLEROSIS PATIENTS AND TARGETED ESSENTIAL FACTORS OF T HELPER17/REGULATORY T-CELLS DIFFERENTIATION. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(3), 277-283. SID. https://sid.ir/paper/715418/en

Vancouver: Copy

MAJD MARYAM, HOSSEINI AREF, GHAEDI KAMRAN, KIANI ESFAHANI ABBAS, TANHAEI SOMAYEH, SHIRALIAN ESFAHANI HANIEH, RAHNAMAEE SEYED YAHYA, MOWLA SEYED JAVAD, NASRESFAHANI MOHAMMAD HOSSEIN. MIR-9-5P AND MIR-106A-5P DYSREGULATED IN CD4⁺ T-CELLS OF MULTIPLE SCLEROSIS PATIENTS AND TARGETED ESSENTIAL FACTORS OF T HELPER17/REGULATORY T-CELLS DIFFERENTIATION. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2018;21(3):277-283. Available from: https://sid.ir/paper/715418/en

IEEE: Copy

MARYAM MAJD, AREF HOSSEINI, KAMRAN GHAEDI, ABBAS KIANI ESFAHANI, SOMAYEH TANHAEI, HANIEH SHIRALIAN ESFAHANI, SEYED YAHYA RAHNAMAEE, SEYED JAVAD MOWLA, and MOHAMMAD HOSSEIN NASRESFAHANI, “MIR-9-5P AND MIR-106A-5P DYSREGULATED IN CD4⁺ T-CELLS OF MULTIPLE SCLEROSIS PATIENTS AND TARGETED ESSENTIAL FACTORS OF T HELPER17/REGULATORY T-CELLS DIFFERENTIATION,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 21, no. 3, pp. 277–283, 2018, [Online]. Available: https://sid.ir/paper/715418/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops