IMMUNOSUPPRESSIVE THERAPY IN CHILDREN WITH STEROID-RESISTANT NEPHROTIC SYNDROME

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JING LI; LI QIN; LU JINMIAO; LI ZHIPING

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Iranian Journal of Pediatrics Year:2018 | Volume:28 | Issue:1 Page(s): 1-6

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Title

IMMUNOSUPPRESSIVE THERAPY IN CHILDREN WITH STEROID-RESISTANT NEPHROTIC SYNDROME

Author(s)

JING LI | LI QIN | LU JINMIAO | LI ZHIPING | Issue Writer Certificate

Keywords

STEROID-RESISTANT NEPHROTIC SYNDROME

IMMUNOSUPPRESSIVE AGENT

REMISSION

RELAPSE

CHILDREN

Abstract

Background: Treatment of STEROID-RESISTANT NEPHROTIC SYNDROME (SRNS) remains a huge challenge in pediatric patients. IMMUNOSUPPRESSIVE AGENTs including cyclosporine A (CsA), tacrolimus (TAC) and mycophenolate mofetil (MMF) are recommended for the management of CHILDREN with SRNS. The aim of this study was to compare the efficacy of CsA, TAC and MMF in CHILDREN with SRNS and provide guidance for clinical practice.Methods: This is a retrospective analysis of the records of 70 CHILDREN with SRNS recruited from a CHILDREN hospital over a period of seven years. They were treated with CsA, TAC and MMF as initial immunosuppressive therapy in addition to steroids. Complete or partial REMISSION was considered a good response.Results: Five (41.7%) of 12 CHILDREN who were on CsA therapy achieved REMISSION at 6 months and 5 (41.7%) at 12 months. Nine (19.1%) of 47 patients treated with TAC achieved REMISSION at 6 months, 20 (42.6%) at 12 months and 6 (12.8%) within or over 24 months. The REMISSION achieved at 6 months and 12 months was 4 (36.4%) and 2 (18.2%) respectively in MMF group. The RELAPSE rates in CHILDREN who had achieved REMISSION were 30.0%, 45.7% and 50.0% in CsA, TAC and MMF group respectively.Conclusions: Based on similar baseline characteristics, CsA and TAC as initial therapy for SRNS have a better REMISSION and RELAPSE rates whereas MMF shows a rapid REMISSION effect.

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APA: Copy

JING, LI, LI, QIN, LU, JINMIAO, & LI, ZHIPING. (2018). IMMUNOSUPPRESSIVE THERAPY IN CHILDREN WITH STEROID-RESISTANT NEPHROTIC SYNDROME. IRANIAN JOURNAL OF PEDIATRICS, 28(1), 1-6. SID. https://sid.ir/paper/716369/en

Vancouver: Copy

JING LI, LI QIN, LU JINMIAO, LI ZHIPING. IMMUNOSUPPRESSIVE THERAPY IN CHILDREN WITH STEROID-RESISTANT NEPHROTIC SYNDROME. IRANIAN JOURNAL OF PEDIATRICS[Internet]. 2018;28(1):1-6. Available from: https://sid.ir/paper/716369/en

IEEE: Copy

LI JING, QIN LI, JINMIAO LU, and ZHIPING LI, “IMMUNOSUPPRESSIVE THERAPY IN CHILDREN WITH STEROID-RESISTANT NEPHROTIC SYNDROME,” IRANIAN JOURNAL OF PEDIATRICS, vol. 28, no. 1, pp. 1–6, 2018, [Online]. Available: https://sid.ir/paper/716369/en

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