OPTIMIZED PREPARATION AND EVALUATION OF 99MTC-STREPTOMYCIN

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BADBARIN ALI; JALILIAN AMIR REZA; YOUSEFNIA HASSAN; MAZIDI MOHAMMAD; BOLOURINOVIN FATEMEH

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Journal: Iranian Journal of Nuclear Medicine Year:2016 | Volume:24 | Issue:1 (SERIAL NUMBER 45) Page(s): 46-50

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Title

OPTIMIZED PREPARATION AND EVALUATION OF 99MTC-STREPTOMYCIN

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Keywords

TECHNETIUM-99M

STREPTOMYCIN

SPECT

BIODISTRIBUTION

Abstract

Introduction: The endemic occurrence of new strains of tuberculosis around the globe has initiated new research on developing diagnostic radiopharmaceutical based on antibiotics.Methods: Tc-99m labeled STREPTOMYCIN was prepared using freshly milked 99mTcO4- and various concentrations of STREPTOMYCIN, stannous chloride at various temperatures in high yield radiochemical purity shown by HPLC/RTLC.Results: At various pHs tested (3-10) the best labeling yield at optimized conditions were at 6-8 range, however pH.7 was considered the best. The radiochemical purity at the best optimized conditions was>95% as shown by RTLC and>97% using HPLC (specific activity; 1-3 GBq/mmole). The tracer proved to be stable in the final product and in presence of human serum at 37°C up to 2h. However, BIODISTRIBUTION and high resolution SPECT studies in wild type mice showed instability of the complex due to high stomach and thyroid activity uptake.Conclusion: Regardless the reported methods in the literature the direct 99mTc-labeling of aminoglycosides did not proved a suitable tracer.

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APA: Copy

BADBARIN, ALI, JALILIAN, AMIR REZA, YOUSEFNIA, HASSAN, MAZIDI, MOHAMMAD, & BOLOURINOVIN, FATEMEH. (2016). OPTIMIZED PREPARATION AND EVALUATION OF ^99MTC-STREPTOMYCIN. IRANIAN JOURNAL OF NUCLEAR MEDICINE, 24(1 (SERIAL NUMBER 45)), 46-50. SID. https://sid.ir/paper/716579/en

Vancouver: Copy

BADBARIN ALI, JALILIAN AMIR REZA, YOUSEFNIA HASSAN, MAZIDI MOHAMMAD, BOLOURINOVIN FATEMEH. OPTIMIZED PREPARATION AND EVALUATION OF ^99MTC-STREPTOMYCIN. IRANIAN JOURNAL OF NUCLEAR MEDICINE[Internet]. 2016;24(1 (SERIAL NUMBER 45)):46-50. Available from: https://sid.ir/paper/716579/en

IEEE: Copy

ALI BADBARIN, AMIR REZA JALILIAN, HASSAN YOUSEFNIA, MOHAMMAD MAZIDI, and FATEMEH BOLOURINOVIN, “OPTIMIZED PREPARATION AND EVALUATION OF ^99MTC-STREPTOMYCIN,” IRANIAN JOURNAL OF NUCLEAR MEDICINE, vol. 24, no. 1 (SERIAL NUMBER 45), pp. 46–50, 2016, [Online]. Available: https://sid.ir/paper/716579/en

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