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Information Journal Paper

Title

Research Paper: Effects of Aloe Vera Gel Extract on Aging-Associated Histological Changes of the Sciatic Nerve

Pages

  89-97

Abstract

 Introduction: Prior qualitative and quantitative studies have reported morphological changesthat occur in nerve fibers and non-neuronal cells of peripheral nerve during the lifetime of therats. Previous studies suggest that Aloe vera has some beneficial and therapeutic effects such asanti-oxidant effects. In the current study, we have evaluated histological and histomorphometricchanges of Sciatic nerve in aged Rats treated with Aloe vera gel extract. Methods: Sixty healthy male albino Sprague-Dawley Rats weighing 200-250 g were randomlydivided into two groups: control (normal diet), and experimental group (normal diet+AloeVera extract). Rats of the experimental group received 400 mg/kg Aloe vera extract daily. Within 16, 20 and 24 months, animals were anesthetized with sodium thiopental (40 mg/kg)via IP injection. After removal of Sciatic nerve on the left side, nerve dissected and fixed in 4%glutaraldehyde, post fixed in osmium tetroxide 1%, dehydrated and then embedded in TAABresin. Thin sections (1 μ m) were stained with toluidine blue stain and ten slides were obtainedfrom each animal and got examined on light microscope. Masson’ s trichrome stain was usedto evaluate the development of fibrosis. Histomorphometric and histologic criteria on Sciaticnerve were determined and data were recorded. Data were analyzed using SPSS software. Results: Results of the current study confirmed accumulation of collagen in the perineuriumby Aging. Our data suggested that Aging caused a decrease in diameter of nerve trunk and nervefibers, thickness of myelin and nerve fiber area. The nerve fascicle diameter decreased in thecontrol group, only. The numbers of myelinated fibers with enfolding into the axoplasm andout folding, irregularity of nerve fibers, myelin sheath with unclear boundaries and alteration inmyelin compaction were also increased. Treatment with Aloe vera gel prevented nerve trunk, as well as fiber and myelin thickness changes. Conclusion: In the current study, we observed some alterations in Sciatic nerve caused byAging, such as accumulation of collagen in perineurieum and endoneurieum. Also, a significantdecrease was seen in nerve fibers, nerve trunks diameter and myelin thickness which werehighly evident in Rats of the 24 months age group. Treatment with Aloe vera gel extractimproved histological changes and retarded Neuropathy signs, significantly.

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    APA: Copy

    BARMAKI, BABAK, GHAFFARI, HAMIDREZA, GHOLAMI, SOGHRA, & Alipoor Tabrizi, Malihe. (2017). Research Paper: Effects of Aloe Vera Gel Extract on Aging-Associated Histological Changes of the Sciatic Nerve. JOURNAL OF IRANIAN ANATOMICAL SCIENCES, 14(3), 89-97. SID. https://sid.ir/paper/716686/en

    Vancouver: Copy

    BARMAKI BABAK, GHAFFARI HAMIDREZA, GHOLAMI SOGHRA, Alipoor Tabrizi Malihe. Research Paper: Effects of Aloe Vera Gel Extract on Aging-Associated Histological Changes of the Sciatic Nerve. JOURNAL OF IRANIAN ANATOMICAL SCIENCES[Internet]. 2017;14(3):89-97. Available from: https://sid.ir/paper/716686/en

    IEEE: Copy

    BABAK BARMAKI, HAMIDREZA GHAFFARI, SOGHRA GHOLAMI, and Malihe Alipoor Tabrizi, “Research Paper: Effects of Aloe Vera Gel Extract on Aging-Associated Histological Changes of the Sciatic Nerve,” JOURNAL OF IRANIAN ANATOMICAL SCIENCES, vol. 14, no. 3, pp. 89–97, 2017, [Online]. Available: https://sid.ir/paper/716686/en

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