COMPARISON OF FREQUENCIES OF NON MOTOR SYMPTOMS IN INDIAN PARKINSON’S DISEASE PATIENTS ON MEDICAL MANAGEMENT VERSUS DEEP BRAIN STIMULATION: A CASE-CONTROL STUDY

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Mridula Kandadai Rukmini; Borgohain Rupam; Jabeen Shaik Afshan; Padmaja Gaddamanugu; Bandaru V.C.S. Srinivasarao; Ankathi Praveen; Kanikannan Meena A.; Ali Khan Mohammed Shujath

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Journal: Current Journal of Neurology Year:2015 | Volume:14 | Issue:2 Page(s): 86-93

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Title

COMPARISON OF FREQUENCIES OF NON MOTOR SYMPTOMS IN INDIAN PARKINSON’S DISEASE PATIENTS ON MEDICAL MANAGEMENT VERSUS DEEP BRAIN STIMULATION: A CASE-CONTROL STUDY

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Keywords

PARKINSON DISEASE

DEEP BRAIN STIMULATION

SUBTHALAMIC NUCLEUS

DOPAMINE AGENTS

COMPREHENSIVE HEALTH CARE

Abstract

Background: Non motor symptoms (NMS) of idiopathic Parkinson’ s disease (PD) are a major cause of disability and recognition of these symptoms and treatment is important for COMPREHENSIVE HEALTH CARE. DEEP BRAIN STIMULATION of bilateral SUBTHALAMIC NUCLEUS DEEP BRAIN STIMULATION (STN DBS) has been shown to improve motor symptoms in PD and effects on NMS are unknown. To investigate the NMS among PD patients who underwent STN DBS. Methods: We recruited prospectively 56 patients with PD, who had undergone bilateral STN DBS and 53 age and duration of illness matched PD patients on dopaminergic therapy (controls). NMS were assessed using 30 item questionnaire NMS Quest. These questions evaluated 9 domains, gastrointestinal, urinary, cardiovascular, sexual, cognition (apathy/attention/memory), anxiety/depression, hallucinations/delusions, sleep and miscellaneous. Comparison was done on individual symptoms as well as in various domains. This study was carried at Nizam’ s Institution of Medical Sciences and study period was from January 2011 to December 2012. Results: Patients who underwent STN DBS had a significantly lower mean total score on NMS quest (6. 7 ± 3. 8) compared to controls (8. 4 ± 3. 7) (P < 0. 00100). Symptoms in the domains of cardiovascular, gastrointestinal, sleep were significantly less frequent while sexual disturbances were significantly more frequent among patients compared to controls. On individual symptom analysis, nocturia (P < 0. 00010), unexplained pains (P < 0. 00010), nausea and vomiting, constipation, lightheadedness, depression, and insomnia were less prevalent, while sexual disturbances were significantly more common in STN DBS group compared to controls. Conclusion: Bilateral STN DBS not only improves the motor symptoms but also improves many NMS in PD patients.

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APA: Copy

Mridula, Kandadai Rukmini, Borgohain, Rupam, Jabeen, Shaik Afshan, Padmaja, Gaddamanugu, Bandaru, V.C.S. Srinivasarao, Ankathi, Praveen, Kanikannan, Meena A., & Ali Khan, Mohammed Shujath. (2015). COMPARISON OF FREQUENCIES OF NON MOTOR SYMPTOMS IN INDIAN PARKINSON’S DISEASE PATIENTS ON MEDICAL MANAGEMENT VERSUS DEEP BRAIN STIMULATION: A CASE-CONTROL STUDY. CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY), 14(2), 86-93. SID. https://sid.ir/paper/716965/en

Vancouver: Copy

Mridula Kandadai Rukmini, Borgohain Rupam, Jabeen Shaik Afshan, Padmaja Gaddamanugu, Bandaru V.C.S. Srinivasarao, Ankathi Praveen, Kanikannan Meena A., Ali Khan Mohammed Shujath. COMPARISON OF FREQUENCIES OF NON MOTOR SYMPTOMS IN INDIAN PARKINSON’S DISEASE PATIENTS ON MEDICAL MANAGEMENT VERSUS DEEP BRAIN STIMULATION: A CASE-CONTROL STUDY. CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY)[Internet]. 2015;14(2):86-93. Available from: https://sid.ir/paper/716965/en

IEEE: Copy

Kandadai Rukmini Mridula, Rupam Borgohain, Shaik Afshan Jabeen, Gaddamanugu Padmaja, V.C.S. Srinivasarao Bandaru, Praveen Ankathi, Meena A. Kanikannan, and Mohammed Shujath Ali Khan, “COMPARISON OF FREQUENCIES OF NON MOTOR SYMPTOMS IN INDIAN PARKINSON’S DISEASE PATIENTS ON MEDICAL MANAGEMENT VERSUS DEEP BRAIN STIMULATION: A CASE-CONTROL STUDY,” CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY), vol. 14, no. 2, pp. 86–93, 2015, [Online]. Available: https://sid.ir/paper/716965/en

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