Mitochondrial Polymorphisms, in The D-Loop Area, Are Associated with Brain Tumors

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Altafi Donya; Sadeghi Soha; Hojatian Hamed; Torabi Afra Maryam; Pakizeh Kar Safoura; Gorji Mojtaba; HOUSHMAND MASSOUD

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Journal: Cell Journal (Yakhteh) Year:2019 | Volume:21 | Issue:3 Page(s): 350-356

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Title

Mitochondrial Polymorphisms, in The D-Loop Area, Are Associated with Brain Tumors

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Keywords

Brain Tumor

D-Loop

Mitochondrial DNA

Abstract

Objective: This study was carried out to evaluate the relationship between mtDNA D-Loop variations and the pathogenesis of a Brain Tumor. Materials and Methods: In this experimental study, 25 specimens of Brain Tumor tissue with their adjacent tissues from patients and 454 blood samples from different ethnic groups of the Iranian population, as the control group, were analysed by the polymerase chain reaction (PCR)-sequencing method. Results: Thirty-six variations of the D-Loop area were observed in Brain Tumor tissues as well as the adjacent normal tissues. A significant difference of A750G (P=0. 046), T15936C (P=0. 013), C15884G (P=0. 013), C16069T (P=0. 049), T16126C (P=0. 006), C16186T (P=0. 022), T16189C (P=0. 041), C16193T (P=0. 045), C16223T (P=0. 001), T16224C (P=0. 013), C16234T (P=0. 013), G16274A (P=0. 009), T16311C (P=0. 038), C16327T (P=0. 045), C16355T (P=0. 003), T16362C (P=0. 006), G16384A (P=0. 042), G16392A (P=0. 013), G16394A (P=0. 013), and G16477A (P=0. 013) variants was found between the patients and the controls. Conclusion: The results indicated individuals with C16069T [odds ratio (OR): 2. 048], T16126C (OR: 2. 226), C16186T (OR: 3. 586), G16274A (OR: 4. 831), C16355T (OR: 7. 322), and T16362C (OR: 6. 682) variants with an OR more than one are probably associated with a Brain Tumor. However, given the multifactorial nature of cancer, more investigation needs to be done to confirm this association.

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References

CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2010-2014

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APA: Copy

Altafi, Donya, Sadeghi, Soha, Hojatian, Hamed, Torabi Afra, Maryam, Pakizeh Kar, Safoura, Gorji, Mojtaba, & HOUSHMAND, MASSOUD. (2019). Mitochondrial Polymorphisms, in The D-Loop Area, Are Associated with Brain Tumors. CELL JOURNAL (YAKHTEH), 21(3), 350-356. SID. https://sid.ir/paper/718657/en

Vancouver: Copy

Altafi Donya, Sadeghi Soha, Hojatian Hamed, Torabi Afra Maryam, Pakizeh Kar Safoura, Gorji Mojtaba, HOUSHMAND MASSOUD. Mitochondrial Polymorphisms, in The D-Loop Area, Are Associated with Brain Tumors. CELL JOURNAL (YAKHTEH)[Internet]. 2019;21(3):350-356. Available from: https://sid.ir/paper/718657/en

IEEE: Copy

Donya Altafi, Soha Sadeghi, Hamed Hojatian, Maryam Torabi Afra, Safoura Pakizeh Kar, Mojtaba Gorji, and MASSOUD HOUSHMAND, “Mitochondrial Polymorphisms, in The D-Loop Area, Are Associated with Brain Tumors,” CELL JOURNAL (YAKHTEH), vol. 21, no. 3, pp. 350–356, 2019, [Online]. Available: https://sid.ir/paper/718657/en

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