مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

253
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

97
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Lack of Association between Selenium Level and Human Epidermal Growth Factor Receptor 2 (HER2) Expression in Breast Cancer Tissue

Pages

  12-14

Abstract

 Background and Objectives: Human epidermal growth factor receptor 2 (HER2) is a gene involved in development of breast cancer. Normally, HER2 receptors control breast cells growth and division. HER2 overexpression is the cause of almost 20% of all breast cancer incidents. The phosphoinositide 3 kinase (PI3K) pathway is important in the oncogenic function of HER2. It has been reported that compounds, such as Selenium significantly attenuate oxidative stress-induced activation of the PI3K pathway, and can exert antitumor effects by downregulating PI3K activation. In this study, we evaluated association of Selenium level and HER2 expression in breast cancer tissue. Methods: Atomic absorption spectrometry and immunohistochemistry were used to evaluate Selenium content and HER2 expression in 30 tissue sets (tumor and adjacent tissue) collected from 30 women diagnosed with breast cancer. Results: HER2 was expressed in about 30% of the samples. In HER2-positive tissues, mean level of Selenium was 268. 15 μ g/L in tumors and 165. 36 μ g/L in tumor margins. In HER2-negative tissues, mean level of Selenium was 206. 43 μ g/L in tumors and 184. 39 μ g/L in tumor margins. There was no significant association between Selenium level and HER2 expression (P>0. 05). Conclusion: Based on the results, we conclude that there is no association between Se level and HER2 expression in breast cancer tissue.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    Salar Amoli, Sanaz, BESHARAT, SIMA, EMAMI RAZAVI, AMIR NADER, & JOSHAGHANI, HAMIDREZA. (2019). Lack of Association between Selenium Level and Human Epidermal Growth Factor Receptor 2 (HER2) Expression in Breast Cancer Tissue. MEDICAL LABORATORY JOURNAL, 13(1), 12-14. SID. https://sid.ir/paper/718749/en

    Vancouver: Copy

    Salar Amoli Sanaz, BESHARAT SIMA, EMAMI RAZAVI AMIR NADER, JOSHAGHANI HAMIDREZA. Lack of Association between Selenium Level and Human Epidermal Growth Factor Receptor 2 (HER2) Expression in Breast Cancer Tissue. MEDICAL LABORATORY JOURNAL[Internet]. 2019;13(1):12-14. Available from: https://sid.ir/paper/718749/en

    IEEE: Copy

    Sanaz Salar Amoli, SIMA BESHARAT, AMIR NADER EMAMI RAZAVI, and HAMIDREZA JOSHAGHANI, “Lack of Association between Selenium Level and Human Epidermal Growth Factor Receptor 2 (HER2) Expression in Breast Cancer Tissue,” MEDICAL LABORATORY JOURNAL, vol. 13, no. 1, pp. 12–14, 2019, [Online]. Available: https://sid.ir/paper/718749/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button