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Title

G-CSF for mobilizing transplanted bone marrow stem cells in rat model of Parkinson's disease

Pages

  1318-1324

Abstract

 Objective(s): Granulocyte-colony stimulating factor (G-CSF) is used in clinical practice for the treatment of neutropenia and to stimulate generation of hematopoietic stem cells in bone marrow donors. In the present study, the ability of G-CSF in mobilizing exogenous Bone marrow stem cells (BMSCs) from peripheral blood into the brain was tested. We for the first time injected a small amount of BMSCs through the tail vein. Materials and Methods: We choose 25 male Wistar rats (200– 250 g) were lesioned by 6-OHDA injected into the left substantia nigra, pars compacta (SNpc). G-CSF (70 μ g/kg/day) was given from the 7th day after lesion for five days. The BMSCs (2×105) were injected through the dorsal tail vein on the 7th day after lesion. Results: The number of rotations was significantly lower in the stem cell therapy group than in the control group. In the third test in the received G-CSF and G-CSF+stem cells groups, animals displayed significant behavioral recovery compared with the control group (P<0. 05). There was a significant difference in the average of Dopaminergic neurons in SNpc between the control group and G-CSF and G-CS+stem cells groups. We didn't detect any labeling stem cells in SNpc. Conclusion: G-CSF can't mobilize low amounts of exogenous BMSCs from the blood stream to injured SNpc. But G-CSF (70 μ g/kg) is more neuroprotective than BMSCs (2×105 number of BMSCs). Results of our study suggest that G-CSF alone is more neuroprotective than BMSCs.

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    APA: Copy

    SAFARI, MANOUCHEHR, Jafari, Behnaz, ZARBAKHSH, SAM, SAMENI, HAMIDREZA, VAFAEI, ABBAS ALI, KHANMOHAMMADI, NASRIN, & GHAHARI, LAYA. (2016). G-CSF for mobilizing transplanted bone marrow stem cells in rat model of Parkinson's disease. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 19(12), 1318-1324. SID. https://sid.ir/paper/719572/en

    Vancouver: Copy

    SAFARI MANOUCHEHR, Jafari Behnaz, ZARBAKHSH SAM, SAMENI HAMIDREZA, VAFAEI ABBAS ALI, KHANMOHAMMADI NASRIN, GHAHARI LAYA. G-CSF for mobilizing transplanted bone marrow stem cells in rat model of Parkinson's disease. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2016;19(12):1318-1324. Available from: https://sid.ir/paper/719572/en

    IEEE: Copy

    MANOUCHEHR SAFARI, Behnaz Jafari, SAM ZARBAKHSH, HAMIDREZA SAMENI, ABBAS ALI VAFAEI, NASRIN KHANMOHAMMADI, and LAYA GHAHARI, “G-CSF for mobilizing transplanted bone marrow stem cells in rat model of Parkinson's disease,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 19, no. 12, pp. 1318–1324, 2016, [Online]. Available: https://sid.ir/paper/719572/en

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