Exercise training has restorative potential on myocardial energy metabolism in rats with chronic heart failure

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WANG LI; Gao kai; Wang dan

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Journal Paper

Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2018 | Volume:21 | Issue:8 Page(s): 818-823

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Title

Exercise training has restorative potential on myocardial energy metabolism in rats with chronic heart failure

Author(s)

WANG LI | Gao kai | Wang dan | Issue Writer Certificate

Keywords

Basal metabolism

Blood pressure

Exercise

Fatty acid

Heart failure

Myocardial infarction

Abstract

Objective(s): Exercise training is a well-known accelerator for the treatment of chronic Heart failure (CHF). The current study aimed to investigate the restorative effects of aerobic interval training (AIT) intervention on myocardial energy metabolism in CHF rats. Materials and Methods: Post-Myocardial infarction (MI) Heart failure animal model was established. The Sprague-Dawley rats were randomly divided into sham operation group (Sham group), CHF model group, and CHF Exercise group (Exercise-CHF group). Results: Our data showed that when compared to the Sham group, the left ventricular systolic pressure (LVSP), myocardial glycogen content, and expression levels of key components of AMP-activated protein kinase (AMPK) pathway were decreased significantly (P<0. 05) in the CHF-model group, while the left ventricular end diastolic pressure (LVEDP), Fatty acid (FA) concentration, lactic acid content, and AMPKα phosphorylation (p-AMPKα ) were increased significantly (P<0. 05) in the CHF-model group. Importantly, AIT reversed these alterations induced by post-MI. Conclusion: Findings of this study demonstrated that AIT could improve the metabolic remodeling and enhance cardiac function, which may be associated with the activation of AMPK/ peroxisome proliferator activated receptor α (PPARα ) and its downstream signaling pathway.

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APA: Copy

WANG, LI, Gao, kai, & Wang, dan. (2018). Exercise training has restorative potential on myocardial energy metabolism in rats with chronic heart failure. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(8), 818-823. SID. https://sid.ir/paper/720355/en

Vancouver: Copy

WANG LI, Gao kai, Wang dan. Exercise training has restorative potential on myocardial energy metabolism in rats with chronic heart failure. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2018;21(8):818-823. Available from: https://sid.ir/paper/720355/en

IEEE: Copy

LI WANG, kai Gao, and dan Wang, “Exercise training has restorative potential on myocardial energy metabolism in rats with chronic heart failure,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 21, no. 8, pp. 818–823, 2018, [Online]. Available: https://sid.ir/paper/720355/en

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