مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Cites:

1

Information Journal Paper

Title

Potential of polymeric particles as future vaccine delivery systems/adjuvants for parenteral and non-parenteral immunization against tuberculosis: A systematic review

Pages

  116-123

Abstract

 Objective(s): Production of effective tuberculosis (TB) Vaccine is necessity. However, the development of new subunit Vaccines is faced with concerns about their weak immunogenicity. To overcome such problems, polymers-based Vaccine delivery systems have been proposed to be used via various routes. The purpose of this study was to determine the potential of Polymeric particles as future Vaccine delivery systems/adjuvants for parenteral and Non-parenteral immunization against TB. Materials and Methods: PubMed, Scopus, Science-Direct, and the ISI web of knowledge databases were searched for related keywords. A total of 420 articles, written up to June 25, 2016, were collected on the potential of Polymeric particles as TB Vaccine delivery systems after parenteral and Non-parenteral immunization. Thirty-one relevant articles were selected by applying inclusion and exclusion criteria. Results: It was shown that the immunogenicity of TB Vaccines had been improved by using biodegradable and non-biodegradable synthetic polymers as well as natural polymers and they are better able to enhance the humoral and cellular immune responses, compared to TB Vaccines alone. The present study revealed that various Polymeric particles, after M. tuberculosis challenge in animal models, provide long-lasting protection against TB. PLGA (poly (lactide-co-glycolide)) and chitosan polymers were widely used as TB Vaccine delivery systems/adjuvants. Conclusion: It seems that PLGA and chitosan polymers are well-suited particles for the parenteral and Non-parenteral administration of TB Vaccines, respectively. Non-biodegradable synthetic polymers in comparison with biodegradable synthetic and natural polymers have been used less frequently. Therefore, further study on this category of polymers is required.

Cites

References

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    • Cite

    APA: Copy

    KHADEMI, FARZAD, DERAKHSHAN, MOHAMMAD, YOUSEFI AVARVAND, ARSHID, & TAFAGHODI, MOHSEN. (2018). Potential of polymeric particles as future vaccine delivery systems/adjuvants for parenteral and non-parenteral immunization against tuberculosis: A systematic review. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(2), 116-123. SID. https://sid.ir/paper/720384/en

    Vancouver: Copy

    KHADEMI FARZAD, DERAKHSHAN MOHAMMAD, YOUSEFI AVARVAND ARSHID, TAFAGHODI MOHSEN. Potential of polymeric particles as future vaccine delivery systems/adjuvants for parenteral and non-parenteral immunization against tuberculosis: A systematic review. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2018;21(2):116-123. Available from: https://sid.ir/paper/720384/en

    IEEE: Copy

    FARZAD KHADEMI, MOHAMMAD DERAKHSHAN, ARSHID YOUSEFI AVARVAND, and MOHSEN TAFAGHODI, “Potential of polymeric particles as future vaccine delivery systems/adjuvants for parenteral and non-parenteral immunization against tuberculosis: A systematic review,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 21, no. 2, pp. 116–123, 2018, [Online]. Available: https://sid.ir/paper/720384/en

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