AdipoRon may be benefit for atherosclerosis prevention

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ESFAHANI MARYAM; SHABAB NOOSHIN; SAIDIJAM MASSOUD

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Journal Paper

Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2017 | Volume:20 | Issue:2 Page(s): 107-109

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Title

AdipoRon may be benefit for atherosclerosis prevention

Author(s)

ESFAHANI MARYAM | SHABAB NOOSHIN | SAIDIJAM MASSOUD | Issue Writer Certificate

Keywords

Adiponectin

Adiponectin receptors

AdipoRon

Atherosclerosis

Cardiovascular diseases

Abstract

Atherosclerosis has serious role in coronary arteries disease, so it is important to establish effective strategies for prevention or even treatment of Atherosclerosis. Adiponectin, as one of the most abundant adipokines, has insulin sensitivity, anti-inflammatory and anti-atherogenic properties. Disturbed Adiponectin actions through its receptor, (AdipoR1 and AdipoR2) may be involved in Atherosclerosis development. Some Adiponectin effects are mediated by AMPK and PPAR-α signaling. AdipoRon is an orally active synthetic molecule which can bind to AdipoR1, Adipo R2 and activate them. AdipoRon can activate AdipoR1-AMPK-PGC-1α pathway and AdipoR2-PPAR-α pathway. Some studies indicated insulin sensitivity, anti-apoptotic and anti-oxidative effect of AdipoRon. We hypothesize that AdipoRon has anti atherosclerotic effect and may suppress Atherosclerosis processes. With confirmation the benefit role of AdipoRon on Atherosclerosis, it may be used in patients at risk of atherosclerotic development.

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APA: Copy

ESFAHANI, MARYAM, SHABAB, NOOSHIN, & SAIDIJAM, MASSOUD. (2017). AdipoRon may be benefit for atherosclerosis prevention. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 20(2), 107-109. SID. https://sid.ir/paper/720696/en

Vancouver: Copy

ESFAHANI MARYAM, SHABAB NOOSHIN, SAIDIJAM MASSOUD. AdipoRon may be benefit for atherosclerosis prevention. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2017;20(2):107-109. Available from: https://sid.ir/paper/720696/en

IEEE: Copy

MARYAM ESFAHANI, NOOSHIN SHABAB, and MASSOUD SAIDIJAM, “AdipoRon may be benefit for atherosclerosis prevention,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 20, no. 2, pp. 107–109, 2017, [Online]. Available: https://sid.ir/paper/720696/en

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