مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Cites:

1

Information Journal Paper

Title

Effect of genistein on expression of pancreatic SIRT1, inflammatory cytokines and histological changes in ovariectomized diabetic rat

Pages

  423-429

Abstract

 Genistein is reported to have anti-diabetic and anti-inflammatory functions, in particular, direct effects on β-cell proliferation and insulin secretion. In this study, we investigated the anti-inflammatory effect of Genistein on the pancreatic β-cells in ovariectomized diabetic rat. Materials and Methods: Forty female rats were divided into four groups: sham, bilateral ovariectomy (OVX), OVX. D (OVX+Diabetes) and OVX. D. G (OVX. D+Genistein). After bilateral ovariectomy, rats in the diabetic groups were fed high-fat diet (HFD), ad libitum for 4 weeks, and then a low dose of streptozotocin (STZ) (30 mg/kg) injected intraperitoneally. Genistein (1 mg/kg/day; SC) was administrated for 8 weeks. At the end of 8 weeks, pancreas tissue was removed and used for western blotting and Hematoxylin-Eosin staining. Results: Treatment with Genistein declined inflammation and tissue injury, and this decline was correlated with the expression of SIRT1. OVX and OVX. D significantly increased Nf-к B and IL-1β expression and decreased SIRT1 levels compared to sham group (P<0. 05). Significant reduction of Nf-к B and IL-1β , and increasing of SIRT1 were observed during Genistein treatment (P<0. 05). Conclusion: Estrogen deficiency alone or with HFD increased pancreatic inflammation. However, subcutaneous administration of gtenistein prevented from these inflammatory changes in the pancreas of a surgery animal model of ovariectomy with or without Diabetes. Our results support the potential preventing effect of Genistein from pancreatic injury.

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    APA: Copy

    YOUSEFI, HADI, ALIHEMMATI, ALIREZA, KARIMI, POURAN, ALIPOUR, MOHAMMAD REZA, HABIBI, PARISA, & AHMADIASL, NASSER. (2017). Effect of genistein on expression of pancreatic SIRT1, inflammatory cytokines and histological changes in ovariectomized diabetic rat. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 20(4), 423-429. SID. https://sid.ir/paper/720876/en

    Vancouver: Copy

    YOUSEFI HADI, ALIHEMMATI ALIREZA, KARIMI POURAN, ALIPOUR MOHAMMAD REZA, HABIBI PARISA, AHMADIASL NASSER. Effect of genistein on expression of pancreatic SIRT1, inflammatory cytokines and histological changes in ovariectomized diabetic rat. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2017;20(4):423-429. Available from: https://sid.ir/paper/720876/en

    IEEE: Copy

    HADI YOUSEFI, ALIREZA ALIHEMMATI, POURAN KARIMI, MOHAMMAD REZA ALIPOUR, PARISA HABIBI, and NASSER AHMADIASL, “Effect of genistein on expression of pancreatic SIRT1, inflammatory cytokines and histological changes in ovariectomized diabetic rat,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 20, no. 4, pp. 423–429, 2017, [Online]. Available: https://sid.ir/paper/720876/en

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