مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

240
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

154
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

2

Information Journal Paper

Title

The effects of ethanol extract of Berberis vulgaris fruit on histopathological changes and biochemical markers of the liver damage in diabetic rats

Pages

  552-556

Abstract

 Objective(s): Various studies have shown that the Diabetes is associated with liver failure. The objective of this study was determining the effects of Berberis vulgaris fruit on histopathological and Biochemical markers of liver in diabetic rats. Materials and Methods: In this experimental study, 60 male Wistar rats weighing 200-250 g with free access to water and ad libitum were randomly divided to five twelve-membered groups including healthy control (group 1), diabetic control (group 2, this two groups received distilled water), treated diabetic positive control (group 3) using dose 150 mg/kg/day metformin, and two groups treated with doses 200 (group 4) and 600 (group 5) mg/kg/BW of B. vulgaris extracts via gavage feeding for 8 weeks. Diabetes mellitus was experimentally induced by one dose injection of alloxan 120 mg/kg. This pre-clinical study was performed on 120 mg/kg alloxan induced diabetic rats. Results: The hepatic steatosis status, liver cholestasis and fibrosis were not changed in group 4 and 5. Glycogen deposition changed mildly and polymorphonuclear neutrophils infiltration changed moderately at group 5. Liver hepatitis changed mildly and severely at group 3 as well as group 5, respectively. Glucose, serum glutamic-oxaloacetic transaminase, serum glutamic pyruvic transaminase, and alkaline phosphatase were lower in high dose group compared to other groups. Conclusion: Results suggested that B. vulgaris extract can decrease liver damage by influencing hepatic histopathological and Biochemical markers in diabetic rats.

Cites

References

  • No record.

    • Cite

    APA: Copy

    RAHIMI MADISEH, MOHAMMAD, Karimian, Paridokht, KAFESHANI, MARZIEH, & RAFIEIAN KOPAEI, MAHMOUD. (2017). The effects of ethanol extract of Berberis vulgaris fruit on histopathological changes and biochemical markers of the liver damage in diabetic rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 20(5), 552-556. SID. https://sid.ir/paper/721173/en

    Vancouver: Copy

    RAHIMI MADISEH MOHAMMAD, Karimian Paridokht, KAFESHANI MARZIEH, RAFIEIAN KOPAEI MAHMOUD. The effects of ethanol extract of Berberis vulgaris fruit on histopathological changes and biochemical markers of the liver damage in diabetic rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2017;20(5):552-556. Available from: https://sid.ir/paper/721173/en

    IEEE: Copy

    MOHAMMAD RAHIMI MADISEH, Paridokht Karimian, MARZIEH KAFESHANI, and MAHMOUD RAFIEIAN KOPAEI, “The effects of ethanol extract of Berberis vulgaris fruit on histopathological changes and biochemical markers of the liver damage in diabetic rats,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 20, no. 5, pp. 552–556, 2017, [Online]. Available: https://sid.ir/paper/721173/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button