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Information Journal Paper

Title

Study of class 1 integrons in multidrug-resistant uropathogenic Escherichia coli isolated from different hospitals in Karachi

Pages

  1079-1082

Abstract

 Objective(s): Escherichia coli is the key pathogen in the family producing ESBL (extended spectrum β-lactamase) and associated with community-acquired infections. Therefore, this study was planned to determine the antibiotic susceptibility pattern of uropathogenic E. coli, prevalence of the ESBL gene group and Class 1 integrons. Materials and Methods: Clinical isolates of uropathogenic E. coli were isolated from different hospitals of Karachi. Antibiotic susceptibility test was performed by Kirby-Bauer Methods. Presence of β – lactamases genes (CTX, TEM, and SHV) and integron 1 were identified by polymerase chain reaction (PCR). Results: Out of 500, 105 isolates were identified as multi-drug resistant (MDR) uropathogenic E. coli. The subject MDR isolates showed the highest resistance to aztreonam, amoxil/ clavulanic acid, ampicillin, cotrimoxazole, ceftriaxone, cefipime, and cefuroxime. Genetic analysis showed that the majority of the MDR E. coli carry CTX M1 (57. 1%) followed by TEM (33. 3%) and SHV (9. 5%). Moreover, 79% of MDR E. coli harbored Class 1 integrons, whereas all three conserved genes for Class 1 integrons were present in 58% of MDR E. coli. Conclusion: This study is helpful to provide information regarding the antibiotic susceptibility pattern, distribution ESBLs and Class 1 integrons among uropathogenic E. coli.

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    Cite

    APA: Copy

    Khan, Fouzia Zeeshan, Nawaz, Tehseen, Mirani, Zulfiqar Ali, Khan, Saeed, Raza, Yasir, & Kazmi, Shahana Urooj. (2018). Study of class 1 integrons in multidrug-resistant uropathogenic Escherichia coli isolated from different hospitals in Karachi. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(10), 1079-1082. SID. https://sid.ir/paper/721217/en

    Vancouver: Copy

    Khan Fouzia Zeeshan, Nawaz Tehseen, Mirani Zulfiqar Ali, Khan Saeed, Raza Yasir, Kazmi Shahana Urooj. Study of class 1 integrons in multidrug-resistant uropathogenic Escherichia coli isolated from different hospitals in Karachi. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2018;21(10):1079-1082. Available from: https://sid.ir/paper/721217/en

    IEEE: Copy

    Fouzia Zeeshan Khan, Tehseen Nawaz, Zulfiqar Ali Mirani, Saeed Khan, Yasir Raza, and Shahana Urooj Kazmi, “Study of class 1 integrons in multidrug-resistant uropathogenic Escherichia coli isolated from different hospitals in Karachi,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 21, no. 10, pp. 1079–1082, 2018, [Online]. Available: https://sid.ir/paper/721217/en

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