Interaction of aquaporin 4 and N-methyl-D-aspartate NMDA receptor 1 in traumatic brain injury of rats

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Chen Li Hua; Zhang Hong Tian; Xu Ru Xiang; Li Wen De; Zhao Hao; YANG YI; SUN KAI

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2018 | Volume:21 | Issue:11 Page(s): 1148-1154

Download Full-Text

View:

185

Download:

Cites:

Information Journal Paper

Title

Interaction of aquaporin 4 and N-methyl-D-aspartate NMDA receptor 1 in traumatic brain injury of rats

Author(s)

Keywords

Aquaporin 4

Edema

N-methyl-D-aspartate

NMDA receptor

NMDAR1

Traumatic brain injury

Abstract

Objective(s):-methyl-D-aspartate NMDA receptor (NMDAR) and Aquaporin 4 (AQP4) are involved in the molecular cascade of Edema after Traumatic brain injury (TBI) and are potential targets of studies in pharmacology and medicine. However, their association and interactions are still unknown. Materials and Methods: We established a rat TBI model in this study. The cellular distribution patterns of AQP4 after inhibition of NMDAR were determined by Western blotting and immunoreactive staining. Furthermore, the regulation of NMDA receptor 1 by AQP4 was studied by injection of a viral vector targeting AQP4 by RNAi into the rat brain before TBI. Results: The results suggest that AQP4 protein expression increased significantly (P<0. 05) after TBI and was down-regulated by the NMDAR inhibitor MK801. This decrease could be partly reversed using the NMDAR agonist NMDA. This indicated that AQP4 mRNA levels and protein expression are regulated by the NMDA signaling pathway. By injection of AQP4 RNAi viral vector into the brain of TBI rat models, we found that the mRNA and protein levels of NMDAR decreased significantly (P<0. 05). This suggested that NMDAR is also regulated by AQP4. Conclusion: These data suggested that the inhibition of AQP4 down-regulates NMDAR expression, which might be one of the mechanisms involved in Edema after TBI.

Cites

No record.

References

No record.

Cite

APA: Copy

Chen, Li Hua, Zhang, Hong Tian, Xu, Ru Xiang, Li, Wen De, Zhao, Hao, YANG, YI, & SUN, KAI. (2018). Interaction of aquaporin 4 and N-methyl-D-aspartate NMDA receptor 1 in traumatic brain injury of rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(11), 1148-1154. SID. https://sid.ir/paper/721281/en

Vancouver: Copy

Chen Li Hua, Zhang Hong Tian, Xu Ru Xiang, Li Wen De, Zhao Hao, YANG YI, SUN KAI. Interaction of aquaporin 4 and N-methyl-D-aspartate NMDA receptor 1 in traumatic brain injury of rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2018;21(11):1148-1154. Available from: https://sid.ir/paper/721281/en

IEEE: Copy

Li Hua Chen, Hong Tian Zhang, Ru Xiang Xu, Wen De Li, Hao Zhao, YI YANG, and KAI SUN, “Interaction of aquaporin 4 and N-methyl-D-aspartate NMDA receptor 1 in traumatic brain injury of rats,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 21, no. 11, pp. 1148–1154, 2018, [Online]. Available: https://sid.ir/paper/721281/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops