Protective effect of Crocus sativus L. (Saffron) extract on spinal cord ischemia-reperfusion injury in rats

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FARJAH GHOLAM HOSSEIN; Salehi Shadi; ANSARI MOHAMMAD HASAN; POURHEIDAR BAGHER

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Journal Paper

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Journal: Iranian Journal of Basic Medical Sciences Year:2017 | Volume:20 | Issue:3 Page(s): 334-337

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Title

Protective effect of Crocus sativus L. (Saffron) extract on spinal cord ischemia-reperfusion injury in rats

Author(s)

FARJAH GHOLAM HOSSEIN | Salehi Shadi | ANSARI MOHAMMAD HASAN | POURHEIDAR BAGHER | Issue Writer Certificate

Keywords

Ischemia

Reperfusion

Spinal cord

Saffron extract

Abstract

Ischemia/Reperfusion (I/R) injury of Spinal cord is leading to the paraplegia observed. In this study, we investigated the protective effect of the Saffron extract on Spinal cord I/R injury. Materials and Methods: Thirty five male Sprague-Dawley rats were divided into 5 groups: intact, sham surgery, normal saline (NS), low dose saffron aqua extract, high dose saffron aqua extract. Results: The mean motor deficit index (MDI) scores were significantly lower in the Saffron extract groups than in the NS group at 48 hr after Spinal cord Ischemia (P<0. 001). Saffron extract groups significantly decreased plasma level of malondialdehyde than in the NS Group (P<0. 05). The number of motor normal neurons was significantly greater in the high Saffron extract group than in the NS and low saffron group (P<0. 05). Conclusion: These data suggest that a Saffron extract may protect Spinal cord neurons from I/R injury.

Cites

Protective effect of lutein on spinal cord ischemia-reperfusion injury in rats

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APA: Copy

FARJAH, GHOLAM HOSSEIN, Salehi, Shadi, ANSARI, MOHAMMAD HASAN, & POURHEIDAR, BAGHER. (2017). Protective effect of Crocus sativus L. (Saffron) extract on spinal cord ischemia-reperfusion injury in rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 20(3), 334-337. SID. https://sid.ir/paper/721401/en

Vancouver: Copy

FARJAH GHOLAM HOSSEIN, Salehi Shadi, ANSARI MOHAMMAD HASAN, POURHEIDAR BAGHER. Protective effect of Crocus sativus L. (Saffron) extract on spinal cord ischemia-reperfusion injury in rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2017;20(3):334-337. Available from: https://sid.ir/paper/721401/en

IEEE: Copy

GHOLAM HOSSEIN FARJAH, Shadi Salehi, MOHAMMAD HASAN ANSARI, and BAGHER POURHEIDAR, “Protective effect of Crocus sativus L. (Saffron) extract on spinal cord ischemia-reperfusion injury in rats,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 20, no. 3, pp. 334–337, 2017, [Online]. Available: https://sid.ir/paper/721401/en

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