مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

218
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

120
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

The effects of bortezomib on the ovariectomy applied rat uterus: A histopathological, stereological, and immunohistochemical study

Pages

  1118-1125

Abstract

 Objective(s): In this study, potential protective effects of Bortezomib (Bort), as a proteasome inhibitor, were investigated on the Uterus of ovariectomized Rats by histological, morphometric and immunohistochemical methods. Materials and Methods: In this study, 18 Sprague dawley strain female Rats (12 weeks old, 250-300 g body weight) were used. Animals in the control group (Cont, n=6) were not exposed to any treatment. Ovariectomy was performed on the experimental groups. They (n=12) were divided into Ovariectomy (Ovt, n=6) and Bortezomib (Bort, n=6) subgroups. Twelve weeks later, the Rats were perfused. Then, uterine tissues were removed and examined by morphometrical, and light and electron Microscopy methods. In addition, immunoreactivity of nuclear factor-kappa (NF-κ B) was evaluated. Results: Morphometric and histopathological evaluations showed that Bort was effective in the Uterus and protects the layer structures and the cells. Conclusion: In the light of these findings, we suggest that for proteasome inhibitor particularly Bort is thought to be useful through proteasome inhibition and NF-κ B pathway

Cites

  • No record.

    • References

    Cite

    APA: Copy

    Khoshvaghti, Habib, & Altunkaynak, Berrin Zuhal. (2018). The effects of bortezomib on the ovariectomy applied rat uterus: A histopathological, stereological, and immunohistochemical study. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(11), 1118-1125. SID. https://sid.ir/paper/721560/en

    Vancouver: Copy

    Khoshvaghti Habib, Altunkaynak Berrin Zuhal. The effects of bortezomib on the ovariectomy applied rat uterus: A histopathological, stereological, and immunohistochemical study. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2018;21(11):1118-1125. Available from: https://sid.ir/paper/721560/en

    IEEE: Copy

    Habib Khoshvaghti, and Berrin Zuhal Altunkaynak, “The effects of bortezomib on the ovariectomy applied rat uterus: A histopathological, stereological, and immunohistochemical study,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 21, no. 11, pp. 1118–1125, 2018, [Online]. Available: https://sid.ir/paper/721560/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button