مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

CircRNA_0109291 regulates cell growth and migration in oral squamous cell carcinoma and its clinical significance

Pages

  1186-1191

Abstract

 Objective(s): Circular RNAs (CircRNAs), a new class of non-coding RNAs, have emerged as important regulators during tumorigenesis. However, the functions of CircRNAs have not been completely clarified in the progression of cancers. In our study, a novel CircRNA Hsa_circ_0109291 was investigated in oral squamous cell carcinoma (OSCC) tissues and cell lines. Materials and Methods: The expression profile of CircRNAs in OSCC tumor tissues was performed by highthroughput sequencing. The CCK-8 wound healing and Apoptosis assay were measured in OSCC cell lines after transfection with si-0109291 or si-NC. Results: We discovered that Hsa_circ_0109291 was significantly increased in OSCC tissues and cell lines compared with their corresponding control group. Knockdown of Hsa_circ_0109291 inhibited proliferation and migration of OSCC cell lines in vitro. In addition, inhibition of Hsa_circ_0109291 dramatically induced Apoptosis of OSCC cells. We further found that high Hsa_circ_0109291 levels in OSCC patients resulted in a poorer Prognosis than in patients with low Hsa_circ_0109291 levels. Conclusion: These findings indicated that Hsa_circ_0109291 correlated with the progression of OSCC and might be a new therapeutic target for the treatment of OSCC.

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    Cite

    APA: Copy

    Ouyang, Shao Bo, WANG, JUN, Zhao, Si Yu, Zhang, Xian Hua, & Liao, Lan. (2018). CircRNA_0109291 regulates cell growth and migration in oral squamous cell carcinoma and its clinical significance. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(11), 1186-1191. SID. https://sid.ir/paper/721566/en

    Vancouver: Copy

    Ouyang Shao Bo, WANG JUN, Zhao Si Yu, Zhang Xian Hua, Liao Lan. CircRNA_0109291 regulates cell growth and migration in oral squamous cell carcinoma and its clinical significance. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2018;21(11):1186-1191. Available from: https://sid.ir/paper/721566/en

    IEEE: Copy

    Shao Bo Ouyang, JUN WANG, Si Yu Zhao, Xian Hua Zhang, and Lan Liao, “CircRNA_0109291 regulates cell growth and migration in oral squamous cell carcinoma and its clinical significance,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 21, no. 11, pp. 1186–1191, 2018, [Online]. Available: https://sid.ir/paper/721566/en

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