مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

The role of TSG-6 and uroplakin III in bladder pain syndrome/ interstitial cystitis in rats and humans

Pages

  1242-1249

Abstract

 Objective(s): We investigated the relationship between the expression of tumor necrosis factor-inducible gene 6 (TSG-6) with inflammation and integrity of the bladder epithelium in the bladder tissues of patients with bladder pain syndrome/interstitial cystitis (BPS/IC) and the mechanism of action using a rat model of BPS/IC. Materials and Methods: Expression of TSG-6 and Uroplakin III was determined by immuno-histochemistry of bladder biopsy samples from control human subjects and patients with verified BPS/IC. Our rat model of BPS/IC was employed to measure the perfusion of bladders with hyaluronidase, and assessment of the effect of TSG-6 administration on disease progression. Treatment effects were assessed by measurement of metabolic characteristics, RT-PCR of TGR-6 and Interleukin-6, bladder histomorphology, and immunohistochemistry of TGR-6 and Uroplakin III. Results: The bladders of patients with BPS/IC had lower expression of Uroplakin III and higher expression of TSG-6 than controls. Rats treated with hyaluronidase for 1 week developed the typical signs and symptoms of BPS/IC, and rats treated with hyaluronidase for 4 weeks had more serious disease. Administration of TSG-6 reversed the effects of hyaluronidase and protected against disease progression. Conclusion: Our results indicate that TSG-6 plays an important role in maintaining the integrity of the bladder epithelial barrier.

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    • Cite

    APA: Copy

    Lv, Yi Song, Gao, Rui, Lin, Qing Ming, Jiang, Tao, Chen, Qin, Tang, Song Xi, Mao, Hou Ping, Zhou, Hui Liang, & Cao, Lin Sheng. (2017). The role of TSG-6 and uroplakin III in bladder pain syndrome/ interstitial cystitis in rats and humans. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 20(11), 1242-1249. SID. https://sid.ir/paper/721607/en

    Vancouver: Copy

    Lv Yi Song, Gao Rui, Lin Qing Ming, Jiang Tao, Chen Qin, Tang Song Xi, Mao Hou Ping, Zhou Hui Liang, Cao Lin Sheng. The role of TSG-6 and uroplakin III in bladder pain syndrome/ interstitial cystitis in rats and humans. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2017;20(11):1242-1249. Available from: https://sid.ir/paper/721607/en

    IEEE: Copy

    Yi Song Lv, Rui Gao, Qing Ming Lin, Tao Jiang, Qin Chen, Song Xi Tang, Hou Ping Mao, Hui Liang Zhou, and Lin Sheng Cao, “The role of TSG-6 and uroplakin III in bladder pain syndrome/ interstitial cystitis in rats and humans,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 20, no. 11, pp. 1242–1249, 2017, [Online]. Available: https://sid.ir/paper/721607/en

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