Therapeutic potential of Juglans regia L. leaf extract against diabetic retinopathy in rat

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NASIRY DAVOOD; KHALATBARY ALI REZA; AHMADVAND HASSAN

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

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Journal: Iranian Journal of Basic Medical Sciences Year:2017 | Volume:20 | Issue:11 Page(s): 1275-1281

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Information Journal Paper

Title

Therapeutic potential of Juglans regia L. leaf extract against diabetic retinopathy in rat

Author(s)

NASIRY DAVOOD | KHALATBARY ALI REZA | AHMADVAND HASSAN | Issue Writer Certificate

Keywords

Antioxidant

Apoptosis

Diabetic retinopathy

Hyperglycemia

Inflammation

Juglans regia L.leaf

Abstract

Objective(s): Oxidative stress has a pivotal role in the pathogenesis of Diabetic retinopathy (DR). Juglans regia L. (JRL) leaf extract has hypoglycemic and antioxidative properties. This study aimed to determine the ameliorative effects of JRL against Diabetic retinopathy. Materials and Methods: The DR rat model was generated by injection of streptozotocin (STZ). A subset of the diabetic rats received JRL or metformin after the onset of Hyperglycemia. Histopathology and immunohistochemistry of apoptotic and inflammatory factors were assessed along with biochemical assessments of lipid peroxidation and Antioxidant status. Results: Lipid peroxidation level and catalase activity significantly improved after JRL consumption (P<0. 001). Degeneration of the retina attenuated after JRL consumption. Attenuation of the caspase-3, COX-2, PARP, and S100B expression could be detected significantly (P<0. 001) in the JRL-treated rats. While, blood glucose level decreased after JRL consumption (P<0. 001). Conclusion: JRL leaf extract exert protective effects against Diabetic retinopathy.

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Internal Septum of Walnut Kernel: a Neglected Functional Food

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APA: Copy

NASIRY, DAVOOD, KHALATBARY, ALI REZA, & AHMADVAND, HASSAN. (2017). Therapeutic potential of Juglans regia L. leaf extract against diabetic retinopathy in rat. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 20(11), 1275-1281. SID. https://sid.ir/paper/721609/en

Vancouver: Copy

NASIRY DAVOOD, KHALATBARY ALI REZA, AHMADVAND HASSAN. Therapeutic potential of Juglans regia L. leaf extract against diabetic retinopathy in rat. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2017;20(11):1275-1281. Available from: https://sid.ir/paper/721609/en

IEEE: Copy

DAVOOD NASIRY, ALI REZA KHALATBARY, and HASSAN AHMADVAND, “Therapeutic potential of Juglans regia L. leaf extract against diabetic retinopathy in rat,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 20, no. 11, pp. 1275–1281, 2017, [Online]. Available: https://sid.ir/paper/721609/en

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