Oral administration of Ginkgolide B alleviates hypoxia-induced neuronal damage in rat hippocampus by inhibiting oxidative stress and apoptosis

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LI WANG; Qinghai Shi; KAI LI; Xue Ma; Lili Niu; Jihua Ran; Zhengxiang Liu; Xiaoling Li; Di Ge; Qi Yang; Mengyun Deng; Jianfeng Fu

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Journal: Iranian Journal of Basic Medical Sciences Year:2019 | Volume:22 | Issue:2 Page(s): 140-145

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Title

Oral administration of Ginkgolide B alleviates hypoxia-induced neuronal damage in rat hippocampus by inhibiting oxidative stress and apoptosis

Author(s)

Keywords

Apoptosis

Ginkgolide B

Hippocampus

Hypoxia

Oxidative stress injury

Abstract

Objective(s): The aim of this study is to explore the potential neuroprotective effects of Ginkgolide B (GB), a main terpene lactone and active component in Ginkgo biloba, in Hypoxia-induced neuronal damage, and to further investigate its possible mechanisms. Materials and Methods: 54 Sprague-Dawley rats were randomly divided into three groups: the untreated control group (n=18); the Hypoxia group (n=18; exposed to 6000 m simulated plateau altitude for six days); and the GB group (n=18; intragastric administration of 12 mg/kg GB three days prior to rapid adaption to 6000 m and on the first two days of Hypoxia). After Hypoxia exposure for six days, we dissected out the brain hippocampi and performed hematoxylin and eosin staining, Nissl staining, and TUNEL staining. Homogenates of the hippocampi were used to test the oxidative stress indices including malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH), and catalase. Bax and caspase-3 expression in the hippocampal tissue was measured using qRT-PCR. Results: Treatment with GB before exposure to Hypoxia could protect neural cells and increase the number of Nissl bodies. TUNEL and qRT-PCR results demonstrated that GB treatment could decrease apoptotic cells in different areas of the Hippocampus. Antioxidant defense systems such as SOD, GSH, and catalase were decreased (P<0. 05), and the concentration of MDA was reduced significantly in the hippocampi of rats of the GB group (P<0. 05). Conclusion: GB could alleviate Hypoxia-induced neuronal damage in rat Hippocampus by inhibiting oxidative stress and Apoptosis.

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APA: Copy

LI, WANG, Qinghai, Shi, KAI, LI, Xue, Ma, Lili, Niu, Jihua, Ran, Zhengxiang, Liu, Xiaoling, Li, Di, Ge, Qi, Yang, Mengyun, Deng, & Jianfeng, Fu. (2019). Oral administration of Ginkgolide B alleviates hypoxia-induced neuronal damage in rat hippocampus by inhibiting oxidative stress and apoptosis. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 22(2), 140-145. SID. https://sid.ir/paper/721620/en

Vancouver: Copy

LI WANG, Qinghai Shi, KAI LI, Xue Ma, Lili Niu, Jihua Ran, Zhengxiang Liu, Xiaoling Li, Di Ge, Qi Yang, Mengyun Deng, Jianfeng Fu. Oral administration of Ginkgolide B alleviates hypoxia-induced neuronal damage in rat hippocampus by inhibiting oxidative stress and apoptosis. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2019;22(2):140-145. Available from: https://sid.ir/paper/721620/en

IEEE: Copy

WANG LI, Shi Qinghai, LI KAI, Ma Xue, Niu Lili, Ran Jihua, Liu Zhengxiang, Li Xiaoling, Ge Di, Yang Qi, Deng Mengyun, and Fu Jianfeng, “Oral administration of Ginkgolide B alleviates hypoxia-induced neuronal damage in rat hippocampus by inhibiting oxidative stress and apoptosis,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 22, no. 2, pp. 140–145, 2019, [Online]. Available: https://sid.ir/paper/721620/en

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