Toxicological evaluation of subchronic use of pioglitazone in mice

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Elshama Said Said; EL KENAWY AYMAN EL MEGHAWRY; HUSSEIN OSMAN HOSAM ELDIN

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Journal Paper

Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2016 | Volume:19 | Issue:7 Page(s): 712-719

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Title

Toxicological evaluation of subchronic use of pioglitazone in mice

Author(s)

Elshama Said Said | EL KENAWY AYMAN EL MEGHAWRY | HUSSEIN OSMAN HOSAM ELDIN | Issue Writer Certificate

Keywords

Mice

Pioglitazone

Sub-chronic use

Toxicity

Abstract

Objective(s): Pioglitazone (Actos) is one of the most controversial recent oral antidiabetic drugs. It was originally authorized in the European Union in 2000, and approved as an oral monotherapy for overweight second type of diabetic patients in 2002. It belongs to the thiazolidinedione group which some of its members have been withdrawn from the market due to the hepatoToxicity or cardioToxicity effects. This study investigates Sub-chronic use of Pioglitazone induced Toxicity in Mice by the assessment of renal and liver function tests, cardiac enzymes, and some hematological indices with histological changes of liver, kidney, heart, and bladder. Materials and Methods: 120 albino Mice were divided into four groups; 30 in each. The first group (control) received water, second (diabetic) group received alloxan only, while the third and the fourth groups received alloxan with 200 and 400 mg/kg/day of Pioglitazone, respectively for 90 days. Results: Prolonged use of Pioglitazone induced significant abnormalities of hepatic, renal, and cardiac biomarkers and some hematological indices associated with histopathological changes in the liver, kidney, heart, and bladder that increased based on administered dose. Conclusion: Subchronic use of Pioglitazone leads to hepatic, renal, cardiac, hematological, and bladder affection depending on the applied dose.

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APA: Copy

Elshama, Said Said, EL KENAWY, AYMAN EL MEGHAWRY, & HUSSEIN OSMAN, HOSAM ELDIN. (2016). Toxicological evaluation of subchronic use of pioglitazone in mice. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 19(7), 712-719. SID. https://sid.ir/paper/721621/en

Vancouver: Copy

Elshama Said Said, EL KENAWY AYMAN EL MEGHAWRY, HUSSEIN OSMAN HOSAM ELDIN. Toxicological evaluation of subchronic use of pioglitazone in mice. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2016;19(7):712-719. Available from: https://sid.ir/paper/721621/en

IEEE: Copy

Said Said Elshama, AYMAN EL MEGHAWRY EL KENAWY, and HOSAM ELDIN HUSSEIN OSMAN, “Toxicological evaluation of subchronic use of pioglitazone in mice,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 19, no. 7, pp. 712–719, 2016, [Online]. Available: https://sid.ir/paper/721621/en

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