The effects of aerobic training before and after the induction of Alzheimer’ s disease on ABCA1 and APOE mRNA expression and the level of soluble Aβ 1-42 in the hippocampus of male Wistar rats

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SARLAK ZAHRA; MOAZZAMI MAHTAB; ATTARZADEH HOSSEINI SEYYED REZA; GHARAKHANLOU REZA

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Journal: Iranian Journal of Basic Medical Sciences Year:2019 | Volume:22 | Issue:4 Page(s): 399-406

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Title

The effects of aerobic training before and after the induction of Alzheimer’ s disease on ABCA1 and APOE mRNA expression and the level of soluble Aβ 1-42 in the hippocampus of male Wistar rats

Author(s)

SARLAK ZAHRA | MOAZZAMI MAHTAB | ATTARZADEH HOSSEINI SEYYED REZA | GHARAKHANLOU REZA | Issue Writer Certificate

Keywords

ABCA1

Aerobic training

Alzheimer’s disease

APOE

Soluble Aβ1-42

Abstract

Objective(s): The purpose of this study was to investigate the effects of Aerobic training before and after the induction of Alzheimer’ s disease on ABCA1 and APOE mRNA expression and the level of soluble Aβ 1-42 in the hippocampus of male Wistar rats. Materials and Methods: Ninety six eight-week-old male Wistar rats were randomly divided into two groups: Training (n=48) and Rest (n=48). After four weeks, each group was randomly divided into two subgroups: intra-hippocampal injection of Aβ 1-42 (n=24) and DMSO (n=24). Then, each group was again randomly divided into two groups: Training (n=12) and Rest (n=12). After four weeks, each group was again randomly divided into two groups: Behavioral test (n=7) and sacrificed (n=5). Results: The one-way ANOVA showed a significant increase in the mRNA expression of ABCA1 (P<0. 05), a significant decrease in the level of soluble Aβ 1-42, and no significant difference in the expression of APOE mRNA (P>0. 05) in the hippocampus as a result of training. The analysis of the Morris water maze data showed that intra-hippocampal injection of Aβ 1-42 impaired spatial learning and memory and exercise improved spatial learning (P<0. 05) and memory (P<0. 05). Conclusion: Therefore, Aerobic training by a significant increase in the mRNA expression of ABCA1, which is the main factors of lipid metabolism in the brain and which is involved in the pathology of Alzheimer’ s disease, can be consistent with improving cognitive function as an effective way of preventing and improving the symptoms of Alzheimer’ s disease.

Cites

The Effect of Combined and Rehabilitation Training on ABCA1 Gene Expression in Blood Lymphocytes and Lipid Profile in Middle-aged Men with Coronary Bypass Graft

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APA: Copy

SARLAK, ZAHRA, MOAZZAMI, MAHTAB, ATTARZADEH HOSSEINI, SEYYED REZA, & GHARAKHANLOU, REZA. (2019). The effects of aerobic training before and after the induction of Alzheimer’ s disease on ABCA1 and APOE mRNA expression and the level of soluble Aβ 1-42 in the hippocampus of male Wistar rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 22(4), 399-406. SID. https://sid.ir/paper/721637/en

Vancouver: Copy

SARLAK ZAHRA, MOAZZAMI MAHTAB, ATTARZADEH HOSSEINI SEYYED REZA, GHARAKHANLOU REZA. The effects of aerobic training before and after the induction of Alzheimer’ s disease on ABCA1 and APOE mRNA expression and the level of soluble Aβ 1-42 in the hippocampus of male Wistar rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2019;22(4):399-406. Available from: https://sid.ir/paper/721637/en

IEEE: Copy

ZAHRA SARLAK, MAHTAB MOAZZAMI, SEYYED REZA ATTARZADEH HOSSEINI, and REZA GHARAKHANLOU, “The effects of aerobic training before and after the induction of Alzheimer’ s disease on ABCA1 and APOE mRNA expression and the level of soluble Aβ 1-42 in the hippocampus of male Wistar rats,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 22, no. 4, pp. 399–406, 2019, [Online]. Available: https://sid.ir/paper/721637/en

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