Protective effects of troxerutin on maternal high-fat diet-induced impairments of spatial memory and apelin in the male offspring

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Diba Roghayeh; MOHADDES GISOU; Mirzaie Bavil Fariba; Farajdokht Fereshteh; Bayandor Parvin; Hosseindoost Maryam; Mehri Keivan; Zavvari Oskuye Zohreh; BABRI SHIRIN

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2018 | Volume:21 | Issue:7 Page(s): 682-687

Download Full-Text

View:

276

Download:

173

Cites:

Information Journal Paper

Title

Protective effects of troxerutin on maternal high-fat diet-induced impairments of spatial memory and apelin in the male offspring

Author(s)

Keywords

Apelin

Maternal high-fat diet

Memory

Morris water maze

Troxerutin

Abstract

Objective(s): Maternal high-fat diet (HFD) is linked with metabolic and cognitive deficits in offspring. Neuroprotective effects of Troxerutin, a natural bioflavonoid, have been reported recently. This study aimed to investigate the effects of Troxerutin on spatial Memory and serum and hippocampal Apelin levels in the male offspring of HFD fed mothers. Materials and Methods: Three-week-old female Wistar rats (n= 40) received HFD or control diet (CD) for 8 weeks. After mating, pregnant animals were divided into two subgroups according to the Troxerutin (TRO) supplementation: CD, CD+TRO, HFD, and HFD+TRO. HFD continued to the end of lactation in HFD and HFD+TRO groups. TRO was gavaged (150 mg/kg/day) during pregnancy. After weaning, the male offspring were fed a normal diet until 12 weeks of age. Spatial Memory was evaluated in the Morris water maze (MWM) on postnatal day (PND) 90. Total Apelin concentration was measured in the serum of maternal rats before mating and after lactation and also in the serum and hippocampus of their male offspring. Results: Both traveled distance (P<0. 05) and time spent (P<0. 05) in the target quadrant were significantly decreased in the offspring of HFD-fed dams, which were reversed by TRO treatment. Moreover, TRO significantly (P<0. 05) decreased serum Apelin levels in dams. Furthermore, TRO treatment in dams significantly (P<0. 05) increased serum and hippocampal levels of Apelin in their offspring. Conclusion: These results indicated that TRO treatment during pregnancy improved maternal HFDinduced spatial Memory impairments of the offspring possibly through modulation of serum and hippocampal Apelin levels.

Cites

References

Cite

APA: Copy

Diba, Roghayeh, MOHADDES, GISOU, Mirzaie Bavil, Fariba, Farajdokht, Fereshteh, Bayandor, Parvin, Hosseindoost, Maryam, Mehri, Keivan, Zavvari Oskuye, Zohreh, & BABRI, SHIRIN. (2018). Protective effects of troxerutin on maternal high-fat diet-induced impairments of spatial memory and apelin in the male offspring. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 21(7), 682-687. SID. https://sid.ir/paper/721640/en

Vancouver: Copy

Diba Roghayeh, MOHADDES GISOU, Mirzaie Bavil Fariba, Farajdokht Fereshteh, Bayandor Parvin, Hosseindoost Maryam, Mehri Keivan, Zavvari Oskuye Zohreh, BABRI SHIRIN. Protective effects of troxerutin on maternal high-fat diet-induced impairments of spatial memory and apelin in the male offspring. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2018;21(7):682-687. Available from: https://sid.ir/paper/721640/en

IEEE: Copy

Roghayeh Diba, GISOU MOHADDES, Fariba Mirzaie Bavil, Fereshteh Farajdokht, Parvin Bayandor, Maryam Hosseindoost, Keivan Mehri, Zohreh Zavvari Oskuye, and SHIRIN BABRI, “Protective effects of troxerutin on maternal high-fat diet-induced impairments of spatial memory and apelin in the male offspring,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 21, no. 7, pp. 682–687, 2018, [Online]. Available: https://sid.ir/paper/721640/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops