Effect of troxerutin on apelin-13, apelin receptors (APJ), and ovarian histological changes in the offspring of high-fat diet fed rats

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Mehri Keyvan; BANAN KHOJASTEH SEYED MAHDI; Farajdokht Fereshteh; Zavvari Oskuye Zohreh; EBRAHIMI HADI; Diba Roghaye; Bayandor Parvin; Hosseindoost Maryam; BABRI SHIRIN

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Journal: Iranian Journal of Basic Medical Sciences Year:2019 | Volume:22 | Issue:6 Page(s): 637-642

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Title

Effect of troxerutin on apelin-13, apelin receptors (APJ), and ovarian histological changes in the offspring of high-fat diet fed rats

Author(s)

Keywords

Apelin-13

APJ receptor

Maternal high-fat diet

Ovarian development

Troxerutin

Abstract

Objective(s): Maternal high-fat diet (HFD) consumption has been linked to metabolic disorders and reproductive dysfunctions in offspring. Troxerutin (TRO) has anti-hyperlipidemic, anti-oxidant, and anti-inflammatory effects. This study examined the effects of TRO on Apelin-13, its receptors mRNA and ovarian histological changes in the offspring of HFD fed rats. Materials and Methods: Female Wistar rats were randomly divided into control diet (CD) or HFD groups and received these diets for eight weeks. After mating, dams were assigned into four subgroups: CD, CD + TRO, HFD, and HFD + TRO, and received their respective diets until the end of lactation. Troxerutin (150 mg/ kg/day) was gavaged in the CD + TRO and HFD + TRO groups during pregnancy. On the postnatal day (PND) 21 all female offspring were separated and fed CD until PND 90. On PND 90 animals were sacrificed and ovarian tissue samples were collected for further evaluation. Results: Results showed that HFD significantly decreased serum Apelin-13 in the female offspring of the HFD dams, which was significantly reversed by TRO. Moreover, real-time polymerase chain reaction (PCR) analysis revealed that TRO treatment significantly decreased the ovarian mRNA expression of the Apelin-13 receptor in the Troxerutin-received offspring. Furthermore, histological examination revealed that TRO increased the number of atretic follicles in the ovaries of HFD+TRO offspring. Conclusion: Maternal high fat feeding compromises ovarian health including follicular growth and development in the adult offspring and Troxerutin treatment improved negative effects of maternal HFD on the Apelin-13 level and Ovarian development of offspring.

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APA: Copy

Mehri, Keyvan, BANAN KHOJASTEH, SEYED MAHDI, Farajdokht, Fereshteh, Zavvari Oskuye, Zohreh, EBRAHIMI, HADI, Diba, Roghaye, Bayandor, Parvin, Hosseindoost, Maryam, & BABRI, SHIRIN. (2019). Effect of troxerutin on apelin-13, apelin receptors (APJ), and ovarian histological changes in the offspring of high-fat diet fed rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 22(6), 637-642. SID. https://sid.ir/paper/722351/en

Vancouver: Copy

Mehri Keyvan, BANAN KHOJASTEH SEYED MAHDI, Farajdokht Fereshteh, Zavvari Oskuye Zohreh, EBRAHIMI HADI, Diba Roghaye, Bayandor Parvin, Hosseindoost Maryam, BABRI SHIRIN. Effect of troxerutin on apelin-13, apelin receptors (APJ), and ovarian histological changes in the offspring of high-fat diet fed rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2019;22(6):637-642. Available from: https://sid.ir/paper/722351/en

IEEE: Copy

Keyvan Mehri, SEYED MAHDI BANAN KHOJASTEH, Fereshteh Farajdokht, Zohreh Zavvari Oskuye, HADI EBRAHIMI, Roghaye Diba, Parvin Bayandor, Maryam Hosseindoost, and SHIRIN BABRI, “Effect of troxerutin on apelin-13, apelin receptors (APJ), and ovarian histological changes in the offspring of high-fat diet fed rats,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 22, no. 6, pp. 637–642, 2019, [Online]. Available: https://sid.ir/paper/722351/en

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