Designing mucoadhesive discs containing stem bark extract of Ziziphus jujuba based on Iranian traditional documents

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Hamedi ShokouhSadat; SHAMS ARDAKANI MOHAMMAD REZA; SADEGHPOUR OMID; AMIN GHOLAMREZA; Haji ghasemali Dawood; ORAFAI HOSSEIN

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Journal: Iranian Journal of Basic Medical Sciences Year:2016 | Volume:19 | Issue:3 Page(s): 330-336

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Title

Designing mucoadhesive discs containing stem bark extract of Ziziphus jujuba based on Iranian traditional documents

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Keywords

Carbopol 934

Mucoadhesive discs

Pharmaceutical tests

PVP(Polyvinylpyrrolidone)

Ziziphus jujuba stem bark

Abstract

Objective (s): Mucoadhesive disc is one of the various routes of drug delivery for curing buccal disease. Materials and Methods: Every discs containing 70 mg stem bark extract of Ziziphus jujuba were formulated by using Carbopol 934, PVP k30 and gelatin as polymers. Discs were made by granulation and direct compression. Discs were standardized based on the total phenol. Properties such as in vitro and in vivo mucoadhesion, drug release, water uptake, and disintegration were carried out. Results: Discs showed excellent mucoadhesion and released high amount of the active ingredients (47%) immediately and completed after approximately the first hour. They had a good adhesion in buccal cavity. Conclusion: This study showed that the kinetics of release of the active substance from the mucoadhesive disc obeyed the zero order kinetic and didn’ t follow the fick’ s law. The water uptake and dissolution (DS), increased with the passing of time.

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APA: Copy

Hamedi, ShokouhSadat, SHAMS ARDAKANI, MOHAMMAD REZA, SADEGHPOUR, OMID, AMIN, GHOLAMREZA, Haji ghasemali, Dawood, & ORAFAI, HOSSEIN. (2016). Designing mucoadhesive discs containing stem bark extract of Ziziphus jujuba based on Iranian traditional documents. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 19(3), 330-336. SID. https://sid.ir/paper/721760/en

Vancouver: Copy

Hamedi ShokouhSadat, SHAMS ARDAKANI MOHAMMAD REZA, SADEGHPOUR OMID, AMIN GHOLAMREZA, Haji ghasemali Dawood, ORAFAI HOSSEIN. Designing mucoadhesive discs containing stem bark extract of Ziziphus jujuba based on Iranian traditional documents. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2016;19(3):330-336. Available from: https://sid.ir/paper/721760/en

IEEE: Copy

ShokouhSadat Hamedi, MOHAMMAD REZA SHAMS ARDAKANI, OMID SADEGHPOUR, GHOLAMREZA AMIN, Dawood Haji ghasemali, and HOSSEIN ORAFAI, “Designing mucoadhesive discs containing stem bark extract of Ziziphus jujuba based on Iranian traditional documents,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 19, no. 3, pp. 330–336, 2016, [Online]. Available: https://sid.ir/paper/721760/en

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