Acute sleep deprivation preconditions the heart against ischemia/ reperfusion injury: the role of central GABA-A receptors

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PARSA HODA; IMANI ALIREZA; FAGHIHI MAHDIEH; RIAHI ESMAIL; BADAVI MOHAMMAD; SHAKOORI ABBAS; RASTEGAR TAYEBEH; AGHAJANI MARJAN; Rajani Sulail Fatima

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Journal: Iranian Journal of Basic Medical Sciences Year:2017 | Volume:20 | Issue:11 Page(s): 1232-1241

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Title

Acute sleep deprivation preconditions the heart against ischemia/ reperfusion injury: the role of central GABA-A receptors

Author(s)

Keywords

Acute sleep deprivation

Bicuculline

GABA-A receptor

Infarct size

Myocardial ischemia/-reperfusion

Nitric oxide

Abstract

Objective(s): Central γ-aminobutyric acid (GABA) neurotransmission modulates cardiovascular functions and sleep. Acute sleep deprivation (ASD) affects functions of various body organs via different mechanisms. Here, we evaluated the effect of ASD on cardiac ischemia/reperfusion injury (IRI), and studied the role of GABA-A receptor inhibition in central nucleus of amygdala (CeA) by assessing Nitric oxide (NO) and oxidative stress. Materials and Methods: The CeA in sixty male Wistar rats was cannulated for saline or Bicuculline (GABA-A receptor antagonist) administration. All animals underwent 30 min of coronary occlusion (ischemia), followed by 2 hr reperfusion (IR). The five experimental groups (n=12) included are as follows: IR: received saline; BIC+IR: received Bicuculline; MLP+IR: received saline, followed by the placement of animals in an aquarium with multiple large platforms; ASD+IR: underwent ASD in an aquarium with multiple small platforms; and BIC+ASD+IR: received Bicuculline prior to ASD. Results: Bicuculline administration increased the malondialdehyde levels and Infarct size, and decreased the NO metabolites levels and endothelial Nitric oxide synthase (eNOS) gene expression in infarcted and non-infarcted areas in comparison to IR group. ASD reduced malondialdehyde levels and Infarct size and increased NO metabolites, corticosterone levels and eNOS expression in infarcted and non-infarcted areas as compared to the IR group. Levels of malondialdehyde were increased while levels of NO metabolites, corticosterone and eNOS expression in infarcted and non-infarcted areas were reduced in the BIC+ASD+IR as compared to the ASD+IR group. Conclusion: Blockade of GABA-A receptors in the CeA abolishes ASD-induced cardioprotection by suppressing oxidative stress and NO production.

Cites

Correlation between adolescent chronic emotional stress and incidence of adult cardiovascular disease in female rats

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APA: Copy

PARSA, HODA, IMANI, ALIREZA, FAGHIHI, MAHDIEH, RIAHI, ESMAIL, BADAVI, MOHAMMAD, SHAKOORI, ABBAS, RASTEGAR, TAYEBEH, AGHAJANI, MARJAN, & Rajani, Sulail Fatima. (2017). Acute sleep deprivation preconditions the heart against ischemia/ reperfusion injury: the role of central GABA-A receptors. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 20(11), 1232-1241. SID. https://sid.ir/paper/721775/en

Vancouver: Copy

PARSA HODA, IMANI ALIREZA, FAGHIHI MAHDIEH, RIAHI ESMAIL, BADAVI MOHAMMAD, SHAKOORI ABBAS, RASTEGAR TAYEBEH, AGHAJANI MARJAN, Rajani Sulail Fatima. Acute sleep deprivation preconditions the heart against ischemia/ reperfusion injury: the role of central GABA-A receptors. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2017;20(11):1232-1241. Available from: https://sid.ir/paper/721775/en

IEEE: Copy

HODA PARSA, ALIREZA IMANI, MAHDIEH FAGHIHI, ESMAIL RIAHI, MOHAMMAD BADAVI, ABBAS SHAKOORI, TAYEBEH RASTEGAR, MARJAN AGHAJANI, and Sulail Fatima Rajani, “Acute sleep deprivation preconditions the heart against ischemia/ reperfusion injury: the role of central GABA-A receptors,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 20, no. 11, pp. 1232–1241, 2017, [Online]. Available: https://sid.ir/paper/721775/en

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